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Supplemental Table 1 |
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Supplemental Table 4 |
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Supplemental Information ISIS splits |
 | Max Planck Institute for Molecular Genetics |
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Deutsche Krebshilfe |
-
Jaeger et al.
Gene expression signatures in melanoma tissuesTable 4 Primary Melanomas
No.
of sample
Tumor no.
Melanoma subtype*)
Vertical
tumor thickness (mm)
Clark
level
Cdc6
Cdk1
DSC1
CCL27
1.
NM1’
NMM
2.33
III
2+
1+
0
3+
2
NM2’
NMM
12,20
V
2+
2+
1+
3+
3.
NM3’
NMM
3,65
III
1+
2+
2+
3+
4.
NM4’
NMM
3.15
IV
2+
1+
1+
3
5.
NM5’
NMM
6.30
V
2+
2+
1+
3+
6.
NM6’
NMM
3.40
IV
2+
1+
1+
2+
7.
NM7’
NMM
2.17
III
1+
1+
1+
2+
8.
NM8’
NMM
3.53
IV
2+
1+
1+
3+
9.
SSM1’
SSM
0.78
III
2+
2+
1+
2+
10.
SSM2’
SSM
0,40
II
1+
1+
1+
2+
11.
SSM3’
SSM
2,39
IV
1+
1+
1+
3+
12.
SSM4’
SSM
1.70
IV
1+
1+
2+
3+
13.
SSM5’
SSM
3.90
III
1+
1+
1+
2+
14.
SSM6’
SSM
1.90
IV
1+
2+
2+
3+
15.
SSM7’
SSM
1.25
IV
1+
1+
1+
2+
16.
SSM8’
SSM
1.70
IV
2+
2+
1+
2+
17.
SSM9’
SSM
2.15
IV
1+
1+
1+
2+
18.
SSM10’
SSM
1.25
IV
1+
1+
2+
3
19.
SSM11’
SSM
2.40
IV
1+
2+
1+
2+
20.
ALM1’
ALM
3.06
IV
2+
2+
0
3+
Metastases
No.
of sample
Tumor
no.
-
-
-
Cdc6
CDK1
DSC1
CCL27
21.
Meta1’
-
-
-
2+
2+
0
1+
22.
Meta2’
-
-
-
2+
1+
0
1+
23.
Meta3’
-
-
-
1+
2+
1+
2
24.
Meta4’
-
-
-
3+
3+
0
2+
25.
Meta5’
-
-
-
3+
3+
1+
1+
26.
Meta6’
-
-
-
3+
2+
2+
1+
27.
Meta7’
-
-
-
3+
3+
0
1+
28.
Meta8’
-
-
-
2+
3+
0
2+
29.
Meta9’
-
-
-
2+
2+
1+
2+
30.
Meta10’
-
-
-
2+
3+
1+
3+
31.
Meta11’
-
-
-
2+
2+
0
2+
32.
Meta12’
-
-
-
3+
3+
0
1+
33.
Meta13’
-
-
-
2+
3+
0
1+
34.
Meta14’
-
-
-
3+
2+
1+
1+
35.
Meta15’
-
-
-
3+
3+
2+
2+
36.
Meta16’
-
-
-
2+
3+
0
2+
37.
Meta17’
-
-
-
2+
2+
0
1+
38.
Meta18’
-
-
-
2+
3+
1+
1+
39.
Meta19’
-
-
-
3+
2+
1+
1+
40.
Meta20’
-
-
-
3+
3+
0
2+
Supplementary Table 4 Immunohistochemical staining patterns of Cdc6, Cdk1, DSC1, and CCL27 in primary melanomas and metastases. An independent set of primary melanomas and metastases was analyzed by immunohistochemistry for the expression of indicated antigens. *)SSM, superficial spreading malignant melanoma; NMM, nodular malignant melanoma; ALM, acrolentiginous malignant melanoma. Differences in staining patterns between primary melanomas and metastases were statistically significant with p<0.001 for Cdc6, Cdk1 and CCL27, and p<0.01 for DSC1.
