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 | Max Planck Institute for Molecular Genetics |
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Deutsche Krebshilfe |
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Jaeger et al.
Gene expression signatures in melanoma tissuesTable 3 No.
Affymetrix ID
Gene
Symbol
GeneDescription
GOTermsBP
Q
value
1.
209351_at
KRT14
keratin 14
structural constituent of cytoskeleton, intermediate filament, epidermis development
<0.01
2.
204268_at
S100A2
S100 calcium binding protein A2
biological process unknown, calcium ion binding, cellular component unknown
<0.01
3.
33323_r_at
SFN
stratifin/14-3-3σ
regulation of progression through cell cycle, extracellular space, cytoplasm, cell proliferation, protein kinase C inhibitor activity, protein domain specific binding
<0.01
4.
33322_i_at
SFN
stratifin/14-3-3σ
regulation of progression through cell cycle, extracellular space, cytoplasm, cell proliferation, protein kinase C inhibitor activity, protein domain specific binding
<0.01
5.
201820_at
KRT5
keratin 5
structural constituent of cytoskeleton, intermediate filament, epidermis development
<0.01
6.
209125_at
KRT6A
keratin 6A
structural constituent of cytoskeleton, intermediate filament, ectoderm development
<0.01
7.
209260_at
SFN
stratifin/14-3-3σ
regulation of progression through cell cycle, extracellular space, cytoplasm, cell proliferation, protein kinase C inhibitor activity, protein domain specific binding
<0.01
8.
213680_at
KRT6B
keratin 6B
structural constituent of cytoskeleton, intermediate filament, ectoderm development
<0.01
9.
202286_s_at
TACSTD2
tumor-associated calcium signal transducer 2
receptor activity, cytosol, integral to plasma membrane, cell surface receptor linked signal transduction, sensory perception, visual perception, cell proliferation, membrane
<0.01
10.
200606_at
DSP
desmoplakin
structural constituent of cytoskeleton, cytoskeleton, intermediate filament, cell-cell adherens junction, epidermis development
<0.01
11.
206400_at
LGALS7
lectin, galactoside-binding, soluble, 7 (galectin 7)
sugar binding, extracellular space, nucleus, apoptosis, heterophilic cell adhesion
<0.01
12.
205916_at
S100A7
S100 calcium binding protein A7 (psoriasin 1)
calcium ion binding, epidermis development
<0.01
13.
202917_s_at
S100A8
S100 calcium binding protein A8 (calgranulin A)
calcium ion binding, extracellular space, inflammatory response
<0.01
14.
205900_at
KRT1
keratin 1
complement activation, lectin pathway, receptor activity, structural constituent of cytoskeleton, protein binding, protein binding, sugar binding, cytoskeleton, intermediate filament,
<0.01
15.
204855_at
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
serine-type endopeptidase inhibitor activity, cell motility
<0.01
16.
203074_at
ANXA8
annexin A8
calcium ion binding, calcium-dependent phospholipid binding, blood coagulation, negative regulation of coagulation
<0.01
17.
204734_at
KRT15
keratin 15
structural constituent of cytoskeleton, intermediate filament, epidermis development
<0.01
18.
39248_at
AQP3
aquaporin 3
transporter activity, membrane fraction, integral to plasma membrane, transport, excretion, membrane
<0.01
19.
217528_at
CLCA2
chloride channel, calcium activated, family member 2
<0.01
20.
206032_at
DSC3
desmocollin 3
calcium ion binding, protein binding, membrane fraction, cytoskeleton, plasma membrane, intercellular junction, cell adhesion, homophilic cell adhesion, integral to membrane
<0.01
21.
212236_x_at
KRT17
keratin 17
structural constituent of cytoskeleton, intermediate filament, epidermis development
<0.01
22.
202504_at
TRIM29
tripartite motif-containing 29
transcription factor activity, intracellular, transcription from RNA polymerase II promoter, zinc ion binding, metal ion binding
<0.01
23.
203407_at
PPL
periplakin
structural constituent of cytoskeleton, protein binding, cytoskeleton, keratinization
<0.01
24.
204971_at
CSTA
cystatin A (stefin A)
cysteine protease inhibitor activity, intracellular
<0.01
25.
206276_at
LY6D
lymphocyte antigen 6 complex, locus D
protein binding, membrane fraction, cell adhesion, membrane
<0.01
26.
221854_at
PKP1
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
signal transducer activity, nucleus, cytoskeleton, intermediate filament, plasma membrane, cell adhesion, signal transduction, cell-cell signaling, intermediate filament binding, desmosome, structural constituent of epidermis
<0.01
27.
205064_at
SPRR1B
small proline-rich protein 1B (cornifin)
structural molecule activity, cytoplasm, intermediate filament, epidermis development, keratinization
<0.01
28.
206165_s_at
CLCA2
chloride channel, calcium activated, family member 2
<0.01
29.
206033_s_at
DSC3
desmocollin 3
calcium ion binding, protein binding, membrane fraction, cytoskeleton, plasma membrane, intercellular junction, cell adhesion, homophilic cell adhesion, integral to membrane
<0.01
30.
210020_x_at
CALML3
calmodulin-like 3
calcium ion binding
<0.01
31.
217744_s_at
PERP
PERP, TP53 apoptosis effector
unknown
<0.01
32.
204952_at
LYPD3
LY6/PLAUR domain containing 3
unknown
<0.01
33.
209863_s_at
TP73L
tumor protein p73-like
transcription factor activity, nucleus, transcription, apoptosis, induction of apoptosis, Notch signaling pathway
<0.01
34.
206642_at
DSG1
desmoglein 1
calcium ion binding, cytoskeleton, intercellular junction assembly, homophilic cell adhesion, calcium-dependent cell-cell adhesion,
<0.01
35.
209800_at
KRT16
keratin 16
structural constituent of cytoskeleton, intermediate filament, cytoskeleton organization and biogenesis, cell proliferation, epidermis development
<0.01
36.
201983_s_at
EGFR
epidermal growth factor receptor
MAP/ERK kinase kinase activity, epidermal growth factor receptor activity, negative regulation of progression through cell cycle, regulation of peptidyl-tyrosine phosphorylation, regulation of nitric-oxide synthase activity, actin filament binding
<0.01
37.
204455_at
DST
dystonin
actin binding, integrin binding, structural constituent of cytoskeleton, calcium ion binding, integrin-mediated signaling pathway, intermediate filament cytoskeleton organization and biogenesis
<0.01
38.
209126_x_at
KRT6B
keratin 6B
structural constituent of cytoskeleton, intermediate filament, ectoderm development
<0.01
39.
213796_at
SPRR1A
small proline-rich protein 1A
structural molecule activity, epidermis development, keratinization
<0.01
40.
212242_at
TUBA1
tubulin, alpha 1 (testis specific)
nucleotide binding, GTPase activity, structural molecule activity, protein binding, GTP binding, microtubule, microtubule-based movement,
<0.01
41.
201131_s_at
CDH1
cadherin 1, type 1, E-cadherin
calcium ion binding, protein binding, homophilic cell adhesion, integral to membrane
<0.01
42.
219936_s_at
GPR87
G protein-coupled receptor 87
rhodopsin-like receptor activity, receptor activity, signal transduction, G-protein coupled receptor protein signaling pathway,
<0.01
43.
213287_s_at
KRT10
keratin 10
structural molecule activity, intermediate filament, epidermis development
<0.01
44.
214164_x_at
CA12
carbonic anhydrase XII
carbonate dehydratase activity, one-carbon compound metabolism, zinc ion binding, integral to membrane, lyase activity, metal ion binding
<0.01
45.
206166_s_at
CLCA2
chloride channel, calcium activated, family member 2
unknown
<0.01
46.
210397_at
DEFB1
defensin, beta 1
extracellular region, response to pest, pathogen or parasite, defense response to bacteria, innate immune response,
<0.01
47.
205157_s_at
KRT17
keratin 17
structural constituent of cytoskeleton, intermediate filament, epidermis development
<0.01
48.
205595_at
DSG3
desmoglein 3 (pemphigus vulgaris antigen)
calcium ion binding, protein binding, cytoskeleton, intercellular junction, cell adhesion
<0.01
49.
215867_x_at
AP1G1
adaptor-related protein complex 1, gamma 1 subunit
transporter activity, binding, Golgi stack, coated pit, protein complex assembly, intracellular protein transport
<0.01
50.
203963_at
CA12
carbonic anhydrase XII
carbonate dehydratase activity, one-carbon compound metabolism, zinc ion binding, integral to membrane,
<0.01
51.
214580_x_at
KRT6A
keratin 6A
structural constituent of cytoskeleton, intermediate filament, ectoderm development
<0.01
52.
207023_x_at
KRT10
keratin 10
structural molecule activity, intermediate filament, epidermis development
<0.01
53.
209212_s_at
KLF5
Kruppel-like factor 5 (intestinal)
DNA binding, RNA polymerase II transcription factor activity, nucleus, transcription, regulation of transcription,
<0.01
54.
203917_at
CXADR
coxsackie virus and adenovirus receptor
receptor activity, protein binding, plasma membrane, integral to plasma membrane, cell adhesion
<0.01
55.
219597_s_at
DUOX1
dual oxidase 1
unknown
<0.01
56.
209771_x_at
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
plasma membrane, humoral immune response
<0.01
57.
217272_s_at
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
serine-type endopeptidase inhibitor activity, cellular component unknown, response to UV, regulation of proteolysis and peptidolysis
<0.01
58.
205051_s_at
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
nucleotide binding, receptor signaling protein tyrosine kinase activity, receptor activity, vascular endothelial growth factor receptor activity, ATP binding, signal transduction,
<0.01
59.
218677_at
S100A14
S100 calcium binding protein A14
calcium ion binding
<0.01
60.
201667_at
GJA1
gap junction protein, alpha 1, 43kDa (connexin 43)
signal transducer activity, protein binding, integral to plasma membrane, connexon complex, cell-cell signaling, heart development, junction assembly,
<0.01
61.
209604_s_at
GATA3
GATA binding protein 3
transcription factor activity, nucleus, transcription, regulation of transcription, DNA-dependent, transcription from RNA polymerase II promoter, defense response,
<0.01
62.
209719_x_at
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serine-type endopeptidase inhibitor activity
<0.01
63.
210715_s_at
SPINT2
serine peptidase inhibitor, Kunitz type, 2
serine-type endopeptidase inhibitor activity, extracellular region, soluble fraction, cell motility
<0.01
64.
202597_at
IRF6
interferon regulatory factor 6
transcription factor activity, nucleus, transcription, regulation of transcription
<0.01
65.
201286_at
SDC1
syndecan 1
integral to plasma membrane, cytoskeletal protein binding, membrane
<0.01
66.
202267_at
LAMC2
laminin, gamma 2
structural molecule activity, protein binding, basement membrane, laminin-5, cell adhesion, heparin binding, epidermis development
<0.01
67.
204870_s_at
PCSK2
proprotein convertase subtilisin/kexin type 2
proprotein convertase 2 activity, subtilase activity, protein binding, proteolysis and peptidolysis, cell-cell signaling,
<0.01
68.
216379_x_at
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
plasma membrane, humoral immune response
<0.01
69.
221841_s_at
KLF4
Kruppel-like factor 4 (gut)
transcription factor activity, nucleus, transcription, negative regulation of cell proliferation, transcriptional activator activity, transcriptional repressor activity
<0.01
70.
209873_s_at
PKP3
plakophilin 3
structural molecule activity, protein binding, nucleus, cytoskeleton, intercellular junction, cell adhesion
<0.01
71.
203961_at
NEBL
nebulette
actin binding, structural constituent of muscle, actin cytoskeleton
<0.01
72.
205185_at
SPINK5
serine peptidase inhibitor, Kazal type 5
serine-type endopeptidase inhibitor activity, antimicrobial humoral response, anti-inflammatory response
<0.01
73.
218002_s_at
CXCL14
chemokine (C-X-C motif) ligand 14
chemotaxis, inflammatory response, signal transduction, cell-cell signaling, chemokine activity
<0.01
74.
213496_at
LPPR4
unknown
<0.01
75.
210633_x_at
KRT10
keratin 10
structural molecule activity, intermediate filament, epidermis development
<0.01
76.
209720_s_at
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serine-type endopeptidase inhibitor activity
<0.01
77.
203726_s_at
LAMA3
laminin, alpha 3
receptor binding, structural molecule activity, basement membrane, epidermis development, regulation of cell adhesion, regulation of cell migration,
<0.01
78.
207324_s_at
DSC1
desmocollin 1
calcium ion binding, protein binding, cytoskeleton, gap junction, cell adhesion,
<0.01
79.
205014_at
FGFBP1
fibroblast growth factor binding protein 1
unknown
<0.01
80.
201015_s_at
JUP
junction plakoglobin
structural molecule activity, membrane fraction, soluble fraction, cytoplasm, cytoskeleton, cell adhesion
<0.01
81.
204379_s_at
FGFR3
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
MAPKKK cascade, nucleotide binding, skeletal development, protein-tyrosine kinase activity, receptor activity, fibroblast growth factor receptor activity, JAK-STAT cascade,
<0.01
82.
266_s_at
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
plasma membrane, humoral immune response
<0.01
83.
218186_at
RAB25
RAB25, member RAS oncogene family
nucleotide binding, GTP binding, intracellular protein transport, small GTPase mediated signal transduction
<0.01
84.
220414_at
CALML5
calmodulin-like 5
calcium ion binding, signal transduction, epidermis development
<0.01
85.
204990_s_at
ITGB4
integrin, beta 4
receptor activity, protein binding, cell-matrix adhesion, integrin-mediated signaling pathway, integrin complex
<0.01
86.
206385_s_at
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
protein binding, cytoskeleton, protein targeting, signal transduction
<0.01
87.
203287_at
LAD1
ladinin 1
structural molecule activity, basement membrane
<0.01
88.
209211_at
KLF5
Kruppel-like factor 5 (intestinal)
DNA binding, RNA polymerase II transcription factor activity, nucleus, transcription, regulation of transcription
<0.01
89.
202712_s_at
CKMT1B
creatine kinase, mitochondrial 1B
creatine kinase activity, mitochondrion
<0.01
90.
40016_g_at
MAST4
microtubule associated serine/threonine kinase family member 4
unknown
<0.01
91.
219476_at
C1orf116
chromosome 1 open reading frame 116
unknown
<0.01
92.
206164_at
CLCA2
chloride channel, calcium activated, family member 2
unknown
<0.01
93.
203638_s_at
FGFR2
fibroblast growth factor receptor 2
nucleotide binding, protein-tyrosine kinase activity, receptor activity, fibroblast growth factor receptor activity, cell growth,
<0.01
94.
209610_s_at
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
membrane fraction, integral to plasma membrane, dicarboxylic acid transport, neutral amino acid transport
<0.01
95.
202350_s_at
MATN2
matrilin 2
calcium ion binding, extracellular matrix
<0.01
96.
203535_at
S100A9
S100 calcium binding protein A9 (calgranulin B)
signal transducer activity, calcium ion binding, inflammatory response, cell-cell signaling
<0.01
97.
214549_x_at
SPRR1A
small proline-rich protein 1A
structural molecule activity, epidermis development
<0.01
98.
204718_at
EPHB6
EPH receptor B6
nucleotide binding, protein-tyrosine kinase activity, receptor activity, ephrin receptor activity, transmembrane receptor protein tyrosine kinase signaling pathway
<0.01
99.
206561_s_at
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
aldehyde reductase activity, electron transporter activity, aldehyde metabolism,
<0.01
100.
219410_at
TMEM45A
transmembrane protein 45A
integral to membrane
<0.01
101.
220225_at
IRX4
iroquois homeobox protein 4
transcription factor activity, nucleus, regulation of transcription
<0.01
102.
212811_x_at
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
membrane fraction, integral to plasma membrane, dicarboxylic acid transport, neutral amino acid transport
<0.01
103.
205109_s_at
ARHGEF4
Rho guanine nucleotide exchange factor (GEF) 4
Rho guanyl-nucleotide exchange factor activity, intracellular signaling cascade
<0.01
104.
210413_x_at
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
serine-type endopeptidase inhibitor activity, immune response, regulation of proteolysis and peptidolysis
<0.01
105.
201287_s_at
SDC1
syndecan 1
integral to plasma membrane, cytoskeletal protein binding,
<0.01
106.
211906_s_at
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
serine-type endopeptidase inhibitor activity, immune response, regulation of proteolysis and peptidolysis
<0.01
107.
218796_at
C20orf42
chromosome 20 open reading frame 42
unknown
<0.01
108.
218980_at
FHOD3
formin homology 2 domain containing 3
unknown
<0.01
109.
219497_s_at
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
nucleic acid binding, transcription,
<0.01
110.
214599_at
IVL
involucrin
cornified envelope, structural molecule activity, cytosol, keratinocyte differentiation,
<0.01
111.
60474_at
C20orf42
chromosome 20 open reading frame 42
unknown
<0.01
112.
211361_s_at
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
serine-type endopeptidase inhibitor activity, regulation of proteolysis and peptidolysis
<0.01
113.
204400_at
EFS
embryonal Fyn-associated substrate
protein binding, cell adhesion, intracellular signaling cascade
<0.01
114.
205363_at
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
iron ion binding, gamma-butyrobetaine dioxygenase activity, oxidoreductase activity, oxidoreductase activity,
<0.01
115.
205220_at
GPR109B
G protein-coupled receptor 109B
rhodopsin-like receptor activity, receptor activity, signal transduction, G-protein coupled receptor protein signaling pathway
<0.01
116.
220289_s_at
AIM1L
absent in melanoma 1-like
unknown
<0.01
117.
219395_at
RBM35B
RNA binding motif protein 35A
unknown
<0.01
118.
219528_s_at
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
nucleic acid binding, tregulation of transcription
<0.01
119.
213385_at
CHN2
chimerin (chimaerin) 2
GSH3/SH2 adaptor activity, GTPase activator activity, intracellular signaling cascade
<0.01
120.
204869_at
PCSK2
proprotein convertase subtilisin/kexin type 2
proprotein convertase 2 activity, subtilase activity, protein binding, proteolysis and peptidolysis,
<0.01
121.
200965_s_at
ABLIM1
actin binding LIM protein 1
actin binding, cytoskeleton organization and biogenesis, actin cytoskeleton
<0.01
122.
219461_at
PAK6
p21(CDKN1A)-activated kinase 6
nucleotide binding, protein serine/threonine kinase activity, protein amino acid phosphorylation
<0.01
123.
211597_s_at
HOP
transcription factor activity, regulation of transcription, DNA-dependent
<0.01
124.
214734_at
SLAC2-B
protein binding, intracellular protein transport, Rab GTPase binding
<0.01
125.
209301_at
CA2
carbonic anhydrase II
carbonate dehydratase activity, cytoplasm, lyase activity,
<0.01
126.
209270_at
LAMB3
laminin, beta 3
structural molecule activity, protein binding, basement membrane, cell adhesion,
<0.01
127.
204636_at
COL17A1
collagen, type XVII, alpha 1
structural molecule activity, extracellular matrix, intercellular junction, phosphate transport, cell-matrix adhesion
<0.01
128.
203453_at
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
ion channel activity, protein binding, membrane fraction, amiloride-sensitive sodium channel activity
<0.01
129.
206677_at
KRTHA1
keratin, hair, acidic, 1
structural constituent of cytoskeleton, intermediate filament, epidermis development
<0.01
130.
39729_at
PRDX2
peroxiredoxin 2
electron transporter activity, cytoplasm, response to oxidative stress, oxidoreductase activity, regulation of apoptosis
<0.01
131.
204942_s_at
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
aldehyde dehydrogenase [NAD(P)+] activity, alcohol metabolism
<0.01
132.
212810_s_at
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
membrane fraction, integral to plasma membrane, transport, dicarboxylic acid transport, neutral amino acid transporter activity,
<0.01
133.
205807_s_at
TUFT1
tuftelin 1
extracellular region, bone mineralization,
<0.01
134.
208153_s_at
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
protein binding, cell adhesion, homophilic cell adhesion, integral to membrane
<0.01
135.
220723_s_at
FLJ21511
unknown
<0.01
136.
209699_x_at
AKR1C2
aldo-keto reductase family 1, member C2
electron transporter activity, lipid metabolism, canalicular bile acid transport, oxidoreductase activity
<0.01
137.
218552_at
ECHDC2
enoyl Coenzyme A hydratase domain containing 2
unknown
<0.01
138.
203797_at
VSNL1
visinin-like 1
calcium ion binding
<0.01
139.
219995_s_at
FLJ13841
<0.01
140.
220016_at
AHNAK
AHNAK nucleoprotein (desmoyokin)
neurogenesis
<0.01
141.
204750_s_at
DSC2
desmocollin 2
protein binding, cytoskeleton, intercellular junction, cell adhesion, homophilic cell adhesion,
<0.01
142.
219825_at
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
monooxygenase activity, iron ion binding, electron transport, membrane
<0.01
143.
220403_s_at
P53AIP1
unknown
<0.01
144.
207109_at
POU2F3
POU domain, class 2, transcription factor 3
transcription factor activity, nucleus, regulation of transcription from RNA polymerase II promoter,
<0.01
145.
207463_x_at
PRSS3
protease, serine, 3 (mesotrypsin)
chymotrypsin activity, trypsin activity, calcium ion binding, proteolysis and peptidolysis,
<0.01
146.
206122_at
SOX15
SRY (sex determining region Y)-box 15
transcription factor activity, RNA polymerase II transcription factor activity, regulation of transcription from RNA polymerase II promoter,
<0.01
147.
207720_at
LOR
loricrin
structural constituent of cytoskeleton
<0.01
148.
209602_s_at
GATA3
GATA binding protein 3
transcription factor activity, nucleus, transcription from RNA polymerase II promoter, morphogenesis
<0.01
149.
205490_x_at
GJB3
gap junction protein, beta 3, 31kDa (connexin 31)
connexon complex, cell communication, perception of sound,
<0.01
150.
206884_s_at
SCEL
sciellin
cytoplasm, zinc ion binding, epidermis development
<0.01
151.
213050_at
COBL
cordon-bleu homolog (mouse)
unknown
<0.01
152.
203780_at
EVA1
epithelial V-like antigen 1
protein binding, cytoskeleton, cell adhesion, homophilic cell adhesion
<0.01
153.
203126_at
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
magnesium ion binding, phosphate metabolism, signal transduction, inositol-1(or 4)-monophosphatase activity,
<0.01
154.
211734_s_at
FCER1A
Fc fragment of IgE, high affinity I, receptor for, alpha polypeptide
receptor activity, receptor signaling protein activity, immune response
<0.01
155.
203021_at
SLPI
secretory leukocyte peptidase inhibitor
serine-type endopeptidase inhibitor activity
<0.01
156.
209792_s_at
KLK10
kallikrein 10
chymotrypsin activity, trypsin activity, proteolysis and peptidolysis, negative regulation of progression through cell cycle
<0.01
157.
221666_s_at
PYCARD
PYD and CARD domain containing
protein binding, induction of apoptosis, cell cycle, signal transduction, caspase activator activity, negative regulation of progression through cell cycle
0.01
158.
215704_at
FLG
filaggrin
structural molecule activity, intermediate filament
0.01
159.
204508_s_at
CA12
carbonic anhydrase XII
carbonate dehydratase activity, zinc ion binding, integral to membrane
0.01
160.
208228_s_at
FGFR2
fibroblast growth factor receptor 2
nucleotide binding, protein-tyrosine kinase activity, receptor activity, fibroblast growth factor receptor activity, cell growth,
0.01
161.
217707_x_at
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
DNA binding, transcription coactivator activity, regulation of transcription from RNA polymerase II promoter,
0.01
162.
219764_at
FZD10
frizzled homolog 10 (Drosophila)
receptor activity, G-protein coupled receptor activity, G-protein coupled receptor protein signaling pathway, Wnt receptor activity
0.01
163.
201425_at
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, electron transporter activity,
0.01
164.
206125_s_at
KLK8
kallikrein 8 (neuropsin/ovasin)
chymotrypsin activity, trypsin activity, proteolysis and peptidolysis
0.01
165.
210347_s_at
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
nucleic acid binding, regulation of transcription
0.01
166.
219197_s_at
SCUBE2
signal peptide, CUB domain, EGF-like 2
unknown
0.01
167.
205403_at
IL1R2
interleukin 1 receptor, type II
receptor activity, interleukin-1, Type II, blocking receptor activity, immune response,
0.01
168.
218963_s_at
KRT23
keratin 23 (histone deacetylase inducible)
structural molecule activity, intermediate filament
0.01
169.
205990_s_at
WNT5A
wingless-type MMTV integration site family, member 5A
receptor binding, signal transduction, frizzled-2 signaling pathway, cell-cell signaling
0.01
170.
215243_s_at
GJB3
gap junction protein, beta 3, 31kDa (connexin 31)
connexon complex, cell communication, connexon channel activity
0.01
171.
213992_at
COL4A6
collagen, type IV, alpha 6
extracellular matrix structural constituent, collagen, cell adhesion, extracellular matrix organization and biogenesis
0.01
172.
206378_at
SCGB2A2
secretoglobin, family 2A, member 2
steroid binding
0.01
173.
206023_at
NMU
neuromedin U
receptor binding, r signal transduction
0.01
174.
205174_s_at
QPCT
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
protein modification, proteolysis and peptidolysis, glutaminyl-peptide cyclotransferase activity, transferase activity
0.01
175.
211002_s_at
TRIM29
tripartite motif-containing 29
transcription factor activity, transcription from RNA polymerase II promoter
0.01
176.
207789_s_at
DPP6
dipeptidylpeptidase 6
catalytic activity, dipeptidyl-peptidase IV activity, proteolysis and peptidolysis
0.01
177.
205778_at
KLK7
kallikrein 7
chymotrypsin activity, trypsin activity, proteolysis and peptidolysis
0.01
178.
214370_at
S100A8
S100 calcium binding protein A8 (calgranulin A)
calcium ion binding, inflammatory response
0.01
179.
202890_at
MAP7
microtubule-associated protein 7
unknown
0.01
180.
204503_at
EVPL
envoplakin
structural molecule activity, cytoskeleton, epidermis development
0.01
181.
203815_at
GSTT1
glutathione S-transferase theta 1
glutathione transferase activity, response to stress
0.01
182.
212543_at
AIM1
absent in melanoma 1
unknown
0.01
183.
219909_at
MMP28
matrix metallopeptidase 28
peptidoglycan metabolism, metalloendopeptidase activity, calcium ion binding, extracellular matrix, proteolysis and peptidolysis,
0.01
184.
220013_at
ABHD9
abhydrolase domain containing 9
unknown
0.01
185.
221796_at
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
nucleotide binding, transmembrane receptor protein tyrosine kinase activity, protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, neurogenesis,
0.01
186.
219630_at
PDZK1IP1
PDZK1 interacting protein 1
integral to membrane
0.01
187.
214451_at
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
transcription factor activity, transcription coactivator activity, regulation of transcription from RNA polymerase II promoter, neurogenesis
0.01
188.
203887_s_at
THBD
thrombomodulin
transmembrane receptor activity, calcium ion binding, blood coagulation, membrane
0.01
189.
202005_at
ST14
suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
chymotrypsin activity, trypsin activity, proteolysis and peptidolysis
0.01
190.
208650_s_at
CD24
CD24 antigen (small cell lung carcinoma cluster 4
antigen)
humoral immune response
0.01
191.
216905_s_at
ST14
suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
chymotrypsin activity, trypsin activity, proteolysis and peptidolysis
0.01
192.
205470_s_at
KLK11
kallikrein 11
proteolysis and peptidolysis
0.01
193.
211653_x_at
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2, bile acid binding protein, 3-alpha hydroxysteroid dehydrogenase, type III)
binding, electron transporter activity, steroid metabolism, canalicular bile acid transport, oxidoreductase activity,
0.01
194.
210461_s_at
ABLIM1
actin binding LIM protein 1
actin binding, cytoskeleton organization and biogenesis, actin cytoskeleton
0.01
195.
219010_at
C1orf106
chromosome 1 open reading frame 106
unknown
0.01
196.
213421_x_at
PRSS3
protease, serine, 3 (mesotrypsin)
chymotrypsin activity, trypsin activity, calcium ion binding, extracellular region, proteolysis and peptidolysis
0.01
197.
204151_x_at
AKR1C1
aldo-keto reductase family 1, member C1
aldo-keto reductase activity, binding, electron transporter activity, oxidoreductase activity, 20-alpha-hydroxysteroid dehydrogenase activity,
0.01
198.
204105_s_at
NRCAM
neuronal cell adhesion molecule
neuron migration, protein binding, central nervous system development, cell-cell adhesion, positive regulation of neuron differentiation
0.01
199.
220724_at
FLJ21511
unknown
0.01
200.
204777_s_at
MAL
mal, T-cell differentiation protein
lipid raft polarization, induction of apoptosis, signal transduction, central nervous system development, structural constituent of myelin sheath, cell differentiation
0.01
201.
218657_at
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
unknown
0.01
202.
210058_at
MAPK13
mitogen-activated protein kinase 13
nucleotide binding, protein serine/threonine kinase activity, MAP kinase activity, protein-tyrosine kinase activity, protein amino acid phosphorylation, cell cycle, protein kinase cascade,
0.01
203.
39249_at
AQP3
aquaporin 3
transporter activity, membrane fraction, excretion
0.01
204.
222303_at
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
transcription factor activity, regulation of transcription
0.01
205.
204753_s_at
HLF
hepatic leukemia factor
double-stranded DNA binding, regulation of transcription, transcription from RNA polymerase II promoter,
0.01
206.
209442_x_at
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
ü protein binding, üGO:0005856: cytoskeleton, protein targeting, signal transduction,
0.01
207.
201328_at
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
transcription factor activity, regulation of transcription
0.01
208.
206030_at
ASPA
aspartoacylase (Canavan disease)
aminoacylase activity, aspartate catabolism, acting on ester bonds
0.01
209.
213217_at
ADCY2
adenylate cyclase 2 (brain)
adenylate cyclase activity, cAMP biosynthesis, intracellular signaling cascade
0.01
210.
219411_at
ELMO3
engulfment and cell motility 3 (ced-12 homolog, C. elegans)
cytoskeleton, GO:0006915: apoptosis,
0.01
211.
63825_at
ABHD2
abhydrolase domain containing 2
catalytic activity, integral to membrane
0.01
212.
213618_at
CENTD1
centaurin, delta 1
unknown
0.01
213.
204751_x_at
DSC2
desmocollin 2
calcium ion binding, protein binding, cytoskeleton, intercellular junction, cell adhesion
0.01
214.
203700_s_at
DIO2
deiodinase, iodothyronine, type II
thyroxine 5'-deiodinase activity, thyroid hormone generation, selenium binding, hormone biosynthesis
0.02
215.
207076_s_at
ASS
argininosuccinate synthetase
urea cycle, nucleotide binding, argininosuccinate synthase activity, protein binding, amino acid biosynthesis, ligase activity
0.02
216.
216918_s_at
DST
dystonin
actin binding, integrin binding, structural constituent of cytoskeleton, calcium ion binding, integrin-mediated signaling pathway, hemidesmosome, intermediate filament cytoskeleton organization and biogenesis
0.02
217.
208156_x_at
EPPK1
epiplakin 1
cytoskeleton
0.02
218.
209603_at
GATA3
GATA binding protein 3
transcription factor activity, transcription, regulation of transcription, transcription from RNA polymerase II promoter,
0.02
219.
201250_s_at
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
transporter activity, glucose transporter activity,
0.02
220.
213929_at
unknown
0.02
221.
203215_s_at
MYO6
myosin VI
microfilament motor activity, actin binding, calmodulin binding, structural constituent of muscle, actin filament-based movement,
0.02
222.
205709_s_at
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
magnesium ion binding, diacylglycerol cholinephosphotransferase activity, phosphatidate cytidylyltransferase activity, phospholipid biosynthesis,
0.02
223.
201829_at
NET1
neuroepithelial cell transforming gene 1
regulation of cell growth, guanyl-nucleotide exchange factor activity, signal transduction
0.02
224.
206363_at
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
chromatin, DNA binding, RNA polymerase II transcription factor activity,
0.02
225.
220646_s_at
KLRF1
killer cell lectin-like receptor subfamily F, member 1
sugar binding, integral to plasma membrane, cell surface receptor linked signal transduction, MHC class I receptor activity
0.02
226.
208407_s_at
CTNND1
catenin (cadherin-associated protein), delta 1
structural molecule activity, protein binding, cytoskeleton, cell-cell adhesion
0.02
227.
204675_at
SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
3-oxo-5-alpha-steroid 4-dehydrogenase activity, electron transporter activity, cell-cell signaling, integral to membrane, oxidoreductase activity
0.02
228.
219850_s_at
EHF
ets homologous factor
unknown
0.02
229.
205455_at
MST1R
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
protein-tyrosine kinase activity, receptor activity, macrophage colony stimulating factor receptor activity, cell motility, signal transduction, positive regulation of cell proliferation
0.02
230.
210059_s_at
MAPK13
mitogen-activated protein kinase 13
nucleotide binding, protein serine/threonine kinase activity, MAP kinase activity, protein-tyrosine kinase activity, protein amino acid phosphorylation, cell cycle,
0.02
231.
213425_at
WNT5A
wingless-type MMTV integration site family, member 5A
receptor binding, signal transduction, frizzled-2 signaling pathway, cell-cell signaling
0.02
232.
213506_at
F2RL1
coagulation factor II (thrombin) receptor-like 1
receptor activity, receptor binding, signal transduction, G-protein coupled receptor protein signaling pathway, blood coagulation, thrombin receptor activity
0.02
233.
202018_s_at
LTF
lactotransferrin
serine-type endopeptidase activity, humoral immune response, metal ion binding
0.02
234.
204351_at
S100P
S100 calcium binding protein P
calcium ion binding, nucleus, calcium-dependent protein binding
0.02
235.
210128_s_at
LTB4R
leukotriene B4 receptor
nucleotide binding, receptor activity, leukotriene receptor activity, cell motility, signal transduction, G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
0.02
236.
209590_at
BMP7
bone morphogenetic protein 7 (osteogenic protein 1)
ossification, cytokine activity, growth factor activity, cell differentiation, growth
0.02
237.
203962_s_at
NEBL
nebulette
actin binding, actin cytoskeleton, regulation of actin filament length
0.02
238.
213369_at
PCDH21
protocadherin 21
unknown
0.02
239.
203786_s_at
TPD52L1
tumor protein D52-like 1
unknown
0.02
240.
205653_at
CTSG
cathepsin G
cathepsin G activity, chymotrypsin activity, trypsin activity, proteolysis and peptidolysis,
0.02
241.
211986_at
AHNAK
AHNAK nucleoprotein (desmoyokin)
nucleus, neurogenesis
0.02
242.
218736_s_at
PALMD
palmdelphin
unknown
0.02
243.
219529_at
CLIC3
chloride intracellular channel 3
voltage-gated chloride channel activity, ion transport, chloride transport, signal transduction
0.02
244.
202489_s_at
FXYD3
FXYD domain containing ion transport regulator 3
ion channel activity, chloride channel activity
0.02
245.
216594_x_at
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase activity, electron transporter activity, oxidoreductase activity, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
0.02
246.
206470_at
PLXNC1
plexin C1
unknown
0.02
247.
212848_s_at
C9orf3
chromosome 9 open reading frame 3
aminopeptidase activity, membrane alanyl aminopeptidase activity, proteolysis and peptidolysis, metallopeptidase activity,
0.02
248.
221815_at
ABHD2
abhydrolase domain containing 2
catalytic activity, integral to membrane
0.02
249.
204136_at
COL7A1
collagen, type VII, alpha 1
serine-type endopeptidase inhibitor activity, protein binding, collagen type VII, basement membrane, cell adhesion
0.02
250.
201189_s_at
ITPR3
inositol 1,4,5-triphosphate receptor, type 3
inositol 1,4,5-triphosphate-sensitive calcium-release channel activity, calcium ion transport, signal transduction
0.02
251.
205554_s_at
DNASE1L3
deoxyribonuclease I-like 3
DNA binding, endonuclease activity, DNA catabolism, apoptosis, hydrolase activity
0.02
252.
205694_at
TYRP1
tyrosinase-related protein 1
monooxygenase activity, copper ion binding, melanin biosynthesis from tyrosine, metabolism
0.02
253.
207134_x_at
TPSB2
tryptase beta 2
chymotrypsin activity, extracellular region, proteolysis and peptidolysis, tryptase activity
0.02
254.
204948_s_at
FST
follistatin
protein binding, development, activin inhibitor activity
0.03
255.
201136_at
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
protein binding, ion transport, chemotaxis,: cytokine and chemokine mediated signaling pathway, chemokine binding
0.03
256.
209386_at
TM4SF1
transmembrane 4 L six family member 1
unknown
0.03
257.
203240_at
FCGBP
Fc fragment of IgG binding protein
unknown
0.03
258.
205251_at
PER2
period homolog 2 (Drosophila)
signal transducer activity transcription, regulation of transcription, DNA-dependent, signal transduction
0.03
259.
203081_at
CTNNBIP1
catenin, beta interacting protein 1
regulation of transcription, DNA-dependent, signal transduction, development, beta-catenin binding, cell proliferation, Wnt receptor signaling pathway
0.03
260.
201008_s_at
TXNIP
thioredoxin interacting protein
unknown
0.03
261.
206471_s_at
PLXNC1
plexin C1
unknown
0.03
262.
204755_x_at
HLF
hepatic leukemia factor
double-stranded DNA binding, regulation of transcription, transcription from RNA polymerase II promoter, development,
0.03
263.
213241_at
PLXNC1
plexin C1
unknown
0.03
264.
210479_s_at
RORA
RAR-related orphan receptor A
transcription factor activity, steroid hormone receptor activity, regulation of transcription, DNA-dependent, signal transduction
0.03
265.
205286_at
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
transcription factor activity regulation of transcription from RNA polymerase II promoter, cell-cell signaling
0.03
266.
203216_s_at
MYO6
myosin VI
microfilament motor activity, nucleotide binding, actin binding, calmodulin binding, GO:0005524: actin filament-based movement,
0.03
267.
213800_at
CFH
complement factor H
extracellular space, immune response, complement activation, alternative pathway
0.03
268.
201650_at
KRT19
keratin 19
structural constituent of cytoskeleton, intermediate filament
0.03
269.
202525_at
PRSS8
protease, serine, 8 (prostasin)
chymotrypsin activity, trypsin activity, proteolysis and peptidolysis
0.03
270.
214896_at
unknown
0.03
271.
204537_s_at
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
GABA-A receptor activity, extracellular ligand-gated ion channel activity, aminobutyric acid signaling pathway, neurotransmitter receptor activity
0.03
272.
206149_at
LOC63928
calcium ion binding
0.03
273.
204223_at
PRELP
proline/arginine-rich end leucine-rich repeat protein
skeletal development, extracellular matrix structural constituent, extracellular matrix
0.03
274.
210426_x_at
RORA
RAR-related orphan receptor A
transcription factor activity, steroid hormone receptor activity, regulation of transcription, DNA-dependent, signal transduction
0.03
275.
205349_at
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
nucleotide binding, GTPase activity, signal transducer activity, GTP binding, heterotrimeric G-protein complex, signal transduction, phospholipase C activation, elevation of cytoplasmic calcium ion concentration
0.03
276.
201613_s_at
RUVBL1
RuvB-like 1 (E. coli)
nucleotide binding, regulation of cell growth, DNA helicase activity, protein binding, DNA recombination, regulation of transcription from RNA polymerase II promoter, chromatin modification
0.03
277.
201984_s_at
EGFR
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
MAP/ERK kinase kinase activity, epidermal growth factor receptor activity, negative regulation of progression through cell cycle, regulation of peptidyl-tyrosine phosphorylation, regulation of nitric-oxide synthase activity, actin filament binding
0.03
278.
203691_at
PI3
peptidase inhibitor 3, skin-derived (SKALP)
serine-type endopeptidase inhibitor activity, protein binding, extracellular matrix
0.03
279.
207955_at
CCL27
chemokine (C-C motif) ligand 27
extracellular space, chemotaxis, immune response, cell-cell signaling, chemokine activity
0.04
280.
205624_at
CPA3
carboxypeptidase A3 (mast cell)
carboxypeptidase activity, proteolysis and peptidolysis, metallopeptidase activity,
0.04
281.
202747_s_at
ITM2A
integral membrane protein 2A
integral to membrane
0.04
282.
208190_s_at
LISCH7
unknown
0.04
283.
219388_at
GRHL2
grainyhead-like 2 (Drosophila)
unknown
0.04
284.
213848_at
DUSP7
dual specificity phosphatase 7
protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein amino acid dephosphorylation, MAP kinase phosphatase activity
0.04
285.
203431_s_at
RICS
unknown
0.04
286.
220428_at
CD207
CD207 antigen, langerin
unknown
0.04
287.
213832_at
unknown
0.04
288.
221610_s_at
STAP2
intracellular signaling cascade
0.04
289.
220266_s_at
KLF4
Kruppel-like factor 4 (gut)
transcription factor activity, nucleus, transcription, negative regulation of cell proliferation, transcriptional activator activity, transcriptional repressor activity
0.04
290.
203585_at
ZNF185
zinc finger protein 185 (LIM domain)
zinc ion binding
0.04
291.
210880_s_at
EFS
embryonal Fyn-associated substrate
protein binding, cell adhesion, intracellular signaling cascade
0.04
292.
206284_x_at
CLTB
clathrin, light polypeptide (Lcb)
calcium ion binding, molecular function unknown, intracellular protein transport
0.04
293.
216474_x_at
TPSAB1
tryptase alpha/beta 1
chymotrypsin activity, proteolysis and peptidolysis, tryptase activity
0.04
294.
203256_at
CDH3
cadherin 3, type 1, P-cadherin (placental)
calcium ion binding, protein binding, cell adhesion, homophilic cell adhesion, sensory perception,
0.04
295.
208483_x_at
KRTHA3A
keratin, acidic, 3A
structural molecule activity, intermediate filament
0.04
296.
220351_at
CCRL1
chemokine (C-C motif) receptor-like 1
rhodopsin-like receptor activity, chemotaxis, signal transduction, G-protein coupled receptor protein signaling pathway, C-C chemokine receptor activity
0.04
297.
206595_at
CST6
cystatin E/M
cysteine protease inhibitor activity, morphogenesis
0.04
298.
208161_s_at
ABCC3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
nucleotide binding, transport, organic anion transporter activity, coupled to transmembrane movement of substances
0.04
299.
208651_x_at
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
plasma membrane, humoral immune response
0.04
300.
203385_at
DGKA
diacylglycerol kinase, alpha 80kDa
diacylglycerol kinase activity, calcium ion binding, protein kinase C activation, intracellular signaling cascade
0.04
301.
209815_at
PTCH
patched homolog (Drosophila)
receptor activity, integral to plasma membrane, cell cycle, signal transduction, hedgehog receptor activity, cell proliferation, negative regulation of progression through cell cycle
0.04
302.
203747_at
AQP3
aquaporin 3
transporter activity, membrane fraction, transport, excretion, membrane
0.04
303.
201249_at
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
transporter activity, sugar porter activity, glucose transporter activity, membrane fraction, carbohydrate transport, glucose transport,
0.04
304.
210084_x_at
TPSAB1
tryptase alpha/beta 1
chymotrypsin activity, proteolysis and peptidolysis, defense response, peptidase activity, tryptase activity, tryptase activity
0.04
305.
41469_at
PI3
peptidase inhibitor 3, skin-derived (SKALP)
serine-type endopeptidase inhibitor activity, protein binding, extracellular matrix
0.04
306.
213154_s_at
BICD2
bicaudal D homolog 2 (Drosophila)
Golgi stack, cytoskeleton
0.04
307.
215813_s_at
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin biosynthesis, prostaglandin-endoperoxide synthase activity, lipid metabolism, oxidoreductase activity, metal ion binding
0.04
308.
215465_at
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
nucleotide binding, ATP binding, lipid transport, integral to membrane, ATPase activity, cell homeostasis
0.04
309.
200920_s_at
BTG1
B-cell translocation gene 1, anti-proliferative
transcription cofactor activity, negative regulation of cell proliferation, cell migration, kinase binding, negative regulation of cell growth, regulation of apoptosis, regulation of transcription, positive regulation of angiogenesis
0.04
310.
209733_at
MID2
midline 2
ubiquitin ligase complex, ubiquitin-protein ligase activity, microtubule associated complex, protein ubiquitination
0.04
311.
209099_x_at
JAG1
jagged 1 (Alagille syndrome)
angiogenesis, cell fate determination, Notch binding, structural molecule activity, cell communication, Notch signaling pathway, neurogenesis, growth factor activity, regulation of cell migration, regulation of cell proliferation,
0.04
312.
217546_at
MT1M
metallothionein 1M
copper ion binding, cadmium ion binding, metal ion binding
0.04
313.
205128_x_at
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
prostaglandin biosynthesis, prostaglandin-endoperoxide synthase activity, lipid metabolism, oxidoreductase activity, metal ion binding
0.04
314.
219496_at
C2orf26
chromosome 2 open reading frame 26
unknown
0.05
315.
219680_at
NOD9
unknown
0.05
316.
204469_at
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
carbonate dehydratase activity, transmembrane receptor protein tyrosine phosphatase activity, integral to plasma membrane, protein amino acid dephosphorylation, central nervous system development,
0.05
317.
205239_at
AREG
amphiregulin (schwannoma-derived growth factor)
cytokine activity, cell-cell signaling, growth factor activity, cell proliferation
0.05
318.
220484_at
MCOLN3
mucolipin 3
cation channel activity, cation transport
0.05
319.
206643_at
HAL
histidine ammonia-lyase
histidine ammonia-lyase activity, histidine catabolism, biosynthesis
0.05
320.
205683_x_at
TPSAB1
tryptase alpha/beta 1
chymotrypsin activity, proteolysis and peptidolysis, defense response, tryptase activity
0.05
321.
210839_s_at
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
nucleic acid binding, endonuclease activity, phosphodiesterase I activity, nucleotide diphosphatase activity, cell motility, chemotaxis, G-protein coupled receptor protein signaling pathway, transcription factor binding
0.05
322.
219241_x_at
SSH3
slingshot homolog 3 (Drosophila)
unknown
0.05
323.
213880_at
LGR5
leucine-rich repeat-containing G protein-coupled receptor 5
receptor activity, integral to plasma membrane, signal transduction, G-protein coupled receptor protein signaling pathway
0.05
324.
205627_at
CDA
cytidine deaminase
cytidine deaminase activity, nucleobase, nucleoside, nucleotide and nucleic acid metabolism, cytidine metabolism
0.05
325.
215126_at
unknown
0.05
326.
202831_at
GPX2
glutathione peroxidase 2 (gastrointestinal)
glutathione peroxidase activity, electron transporter activity, response to oxidative stress, oxidoreductase activity
0.05
327.
219836_at
ZBED2
zinc finger, BED-type containing 2
DNA binding, metal ion binding
0.05
328.
51192_at
SSH3
slingshot homolog 3 (Drosophila)
unknown
0.05
329.
209392_at
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
nucleic acid binding, endonuclease activity, phosphodiesterase I activity, nucleotide diphosphatase activity, cell motility, chemotaxis, G-protein coupled receptor protein signaling pathway, transcription factor binding
0.05
330.
209289_at
NFIB
nuclear factor I/B
transcription factor activity, DNA replication, regulation of transcription
0.05
331.
219368_at
NAP1L2
nucleosome assembly protein 1-like 2
chromatin assembly complex, nucleosome assembly
0.05
332.
203798_s_at
VSNL1
visinin-like 1
calcium ion binding
0.05
Supplementary Table 3 List of up-regulated genes in melanoma metastases compared with primary melanomas. 389 differentially expressed probe sets (representing 308 genes) between melanoma metastases and primary melanomas were identified with a FDR <0.05. Of these, 332 probe sets showed down-regulation in metastases and are listed in this table together with their main biological functions. Q value indicates FDR after applying 10,000 permutations (see Materials and methods section).
