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Courses in Practical DNA Microarray Analysis 2007
2007 March 5-8 in Heidelberg
Registration is closed.
To get on the waiting-list, please send a short note that explains your existing skills and experience with (a) microarrays, (b) statistics, and (c) computer programming and your motivation for taking this course to t.beissbarth@dkfz.de.
If you bring your own laptop, be sure to have installed the following packages:
affy, Biobase, marray, multtest, limma, vsn, arrayMagic, cluster, RColorBrewer, hgu95av2, hgu95av2cdf, estrogen,
ALL, annotate, genefilter, multtest, ROC, isis, pamr, e1071, MCRestimate, GlobalAncova, globaltest, GOstats,
hgu133a, Rgraphviz.
Datasets and additional packages used in the practical sessions can be found in the data directory, links to the tutorial slides and practical exercises in the table below.
Preliminary Course schedule
Monday, Mar 5 - First Analysis steps |
09.00-09.30 |
Introduction and overview |
Benedikt Brors |
09.30-12.30 |
Quality control, normalization and design |
Tim Beissbarth |
14.00-17.00 |
Exercises: Introduction to R, cDNA data, affy data |
Beissbarth, Brors |
Tuesday, Mar 6 - Exploratory analysis |
09.00-10.30 |
Differential gene expression |
Anja von Heydebreck |
10.30-12.00 |
Clustering |
Jörg Rahnenfüührer |
12.00-13.00 |
Annotation |
Benedikt Brors |
14.00-17.00 |
Exercises: Differential gene expression Clustering |
Rahnenführer, Heydebreck |
Wednesday, Mar 7 - Molecular Diagnosis |
09.00-10.30 |
Molecular Diagnosis |
Rainer Spang |
10.30-11.30 |
Classification with PAM and Random Forest |
Markus Ruschhaupt |
11.30-12.30 |
Model Assessment and Selection |
Rainer Spang |
13.30-17.00 |
Exercises: Molecular Diagnosis |
Ruschhaupt, Spang |
Thursday, Mar 8 - Pathways |
09.00-10.00 |
Computational Inference of Cellular Networks |
Achim Tresch |
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10.15-11.15 |
Group testing: global tests, holistic approaches |
Ulrich Mansmann |
11.30-12.30 |
Scoring Gene Ontology terms |
Adrian Alexa |
13.30-17.00 |
Exercises: Group testing and time to work on your own data |
Mansmann, Hummel, Alexa |
Background Knowledge
Ideally, you are interested in mathematical and statistical problems and are familiar with at least one programming language. This course focusses on the practical side of gene expression data analysis. However, data analysis without understanding the statistical background is in general impossible. We strongly recommend you to refresh your mathematical and programming skills before attending the course.
Please use the links to software and literature to prepare yourself before the course begins.
R and Bioconductor
In the afternoon exercises you will learn how to analyze data using the statistical computing environment R [http://www.r-project.org] and BioConductor [http://www.bioconductor.org], an open source software for bioinformatics.
R sources and package sources can be downloaded from The Comprehensive R Archive Network at http://cran.r-project.org.
This is a course in microarray analysis -- not an introduction to R. Please read the Introduction to R before the course begins.
Bring your own data
You are encouraged to bring some of your own data to the course (e.g. genepix files or CEL/CDF). We will use this during the exercises. If you expect to have own data only later in the year, it may in fact be advantageous also to register for one of the later courses.
Participants
Subramanian Arun Kumar | University of Reading | United Kingdom | Cancelled |
Jean-Marc Neefs | Johnson&Johnson | Belgium | |
Alberto Calabro | DKFZ | Germany | |
Dido Lenze | Charité-Universitätsmedizin Berlin, Inst. f. Pat | Germany | Cancelled |
Michael Hummel | Charité-Universitätsmedizin Berlin, Inst. f. Pat | Germany | |
Alessandra Chesi | SISSA | Italy | Cancelled |
Regine Brandt | Klinikum Mannheim | Germany | Cancelled |
Alon Magen | Max Planck Institute for Molecular Genetics | Germany | |
Vincent Negre | INSERM | France | |
Riccarda Rischatsch | Biozentrum University of Basel | Switzerland | |
Rabea Hall | Uniklinik Bonn/ Medizinische Klinik I | Germany | |
Valeria Lima Passos | Maastricht University | Netherlands | |
Mohsen Hajheidari | Max-planck Institute for plant breeding research | Germany | Cancelled |
Tariq Maqbool | INSERM U-384, Faculty of Medicine | France | Cancelled |
Qihua Tan | Odense University Hospital | Denmark | |
Mads Thomassen | Odense University Hospital | Denmark | |
Ingrid Arijs | KU Leuven, faculty of medicine | Belgium | |
Kristel Van Steen | Ghent University Hospital | Belgium | |
Dennis Janz | Institut für Forstbotanik/Universität Göttingen | Germany | |
Christian Otuteye | CUBIC-Cologne University of Bioinformatics Cente | Germany | |
Smita Sudheer | Max Planck Institute for Molecular Genetics | Germany | |
Radek Blatny | Institute of Molecular Genetics | Czech Republic | |
Vibe Skov | Odense University Hospital | Denmark | |
Wiebke Werft | DKFZ | Germany | |
Song Guo | CUBIC Center University Cologne | Germany | |
Dilafruz Juraeva | Cologne University | Germany | |
Alexandr Goncearenco | CUBIC Center University Cologne | Germany | |
Ranjana Bhatia | CUBIC-Cologne University Bioinformatics Centre | Germany | |
Ephraim Teffera | CUBIC-Cologne University Bioinformatics Centre | Germany | |
Hans-Ulrich Klein | Uni Münster/Institut Med.-Inf. und Biomathematik | Deutschland | |
Markus Greiner | Universitätsklinum des Saarlandes | Germany | |
Ion Roxana | Janssen Pharmaceutica nv | Belgium | |
Sheena Pinto | DKFZ | Germany | |
ala hejazi | saad specialist hospital | KSA | Waiting List |
Guido Klingbeil | DKFZ Heidelberg (Theoretische Bioinformatik) | Germany | Waiting List |
Andrea Soltysova | Fac. of sciences UK, dep.of molecular biology | Slovakia | Waiting List |
Kannabiran Nandakumar | DKFZ | germany | |
Mudduluru Giridhar | DKFU | Germany | Waiting List |
Van-Duc Luu | DKFZ | Germany | |
Laura Giannino | Istituto Sperim. Italiano Lazzaro Spallanzani | Italy | Waiting List |
Touati Benoukraf | CIML CNRS-INSERM | France | Waiting List |
jos de graaf | EMBL | germany | |
Thank you for registering!
If you will not be able to attend, please contact Tim Beißbarth as soon as possible so that we can notify the people on the waiting list.
How to find us
We meet Monday, March 5., at 9am at the IPMB building,
in the computer room in the 3rd floor.
The IPMB lies on the science campus of the university of Heidelberg, "Im Neuenheimer Feld", building 364 (see
map).
The closest airport (by time, not by distance) is Frankfurt/Main. It is
approximately 90km away, but has a nice high-speed train connection to
Heidelberg via Mannheim. Travel by train is about 1 hour. Other airports would
be Karlsruhe/Baden Airport and Stuttgart. Travel directions are at the
DKFZ web site, too.
Accomodation
You will need to make your own accommodation arrangements.
Further information
Please contact Tim Beissbarth: t.beissbarth@dkfz.de.
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