GO:0007242

GO:0007242

intracellular signaling cascade (annotated genes)

Biological Process

Parent node

GO:0007242	intracellular signaling cascade

This leaf node contains 312 genes

The following 10 of these are used in classification:

	Symbol	Genename	T-ALL score	other score
2059_s_at	LCK	lymphocyte-specific protein tyrosine kinase	1.8376	-0.282
33238_at	LCK	lymphocyte-specific protein tyrosine kinase	1.7012	-0.261
38147_at	SH2D1A	SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)	1.2761	-0.1958
38949_at	PRKCQ	protein kinase C, theta	0.9056	-0.139
1426_at	SLA	Src-like-adaptor	0.6293	-0.0966
38242_at	BLNK	B-cell linker	-0.5124	0.0786
38893_at	NCF4	neutrophil cytosolic factor 4, 40kDa	-0.3429	0.0526
39319_at	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.1274	-0.0196
38894_g_at	NCF4	neutrophil cytosolic factor 4, 40kDa	-0.1086	0.0167
1085_s_at	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	-0.0691	0.0106

Performance on training data

• Error rate: 0
• Performance: 0.01388
• Redundancy: 6.32838

	Sensitivity	Specificity
T-ALL	1	1
other	1	1

Performance on test data

• Error rate: 0.02752
• Performance: 0.2712
• Redundancy: 6.24713

	Sensitivity	Specificity
T-ALL	0.85714	0.98947
other	0.98947	0.85714

Predictions

	Class	T-ALL	other	Predictionn
BCR-ABL-1	other	2e-05	0.99998	other
BCR-ABL-2	other	0.00052	0.99948	other
BCR-ABL-3 (testset)	other	0	1	other
BCR-ABL-4	other	1e-05	0.99999	other
BCR-ABL-5	other	3e-05	0.99997	other
BCR-ABL-6 (testset)	other	0	1	other
BCR-ABL-7 (testset)	other	0.00223	0.99777	other
BCR-ABL-8 (testset)	other	0	1	other
BCR-ABL-9 (testset)	other	0	1	other
BCR-ABL-C1 (testset)	other	5e-05	0.99995	other
BCR-ABL-Hyperdip-10 (testset)	other	2e-05	0.99998	other
BCR-ABL-Hyperdip-R5	other	1e-05	0.99999	other
BCR-ABL-R1	other	6e-05	0.99994	other
BCR-ABL-R2	other	0.00019	0.99981	other
BCR-ABL-R3 (testset)	other	9e-05	0.99991	other
E2A-PBX1-10	other	3e-05	0.99997	other
E2A-PBX1-11	other	1e-05	0.99999	other
E2A-PBX1-12 (testset)	other	3e-05	0.99997	other
E2A-PBX1-13	other	0.00081	0.99919	other
E2A-PBX1-1	other	2e-05	0.99998	other
E2A-PBX1-2	other	7e-05	0.99993	other
E2A-PBX1-3	other	3e-05	0.99997	other
E2A-PBX1-4 (testset)	other	1e-05	0.99999	other
E2A-PBX1-5	other	5e-05	0.99995	other
E2A-PBX1-6	other	0	1	other
E2A-PBX1-7	other	3e-05	0.99997	other
E2A-PBX1-8	other	0.00062	0.99938	other
E2A-PBX1-9	other	0.00139	0.99861	other
E2A-PBX1-2M1	other	4e-05	0.99996	other
E2A-PBX1-C10	other	0.00167	0.99833	other
E2A-PBX1-C11	other	2e-05	0.99998	other
E2A-PBX1-C12	other	0.00023	0.99977	other
E2A-PBX1-C1	other	0.0029	0.9971	other
E2A-PBX1-C2	other	0.00039	0.99961	other
E2A-PBX1-C3 (testset)	other	0	1	other
E2A-PBX1-C4	other	7e-05	0.99993	other
E2A-PBX1-C5 (testset)	other	7e-05	0.99993	other
E2A-PBX1-C6	other	0	1	other
E2A-PBX1-C7	other	1e-05	0.99999	other
E2A-PBX1-C8	other	0.02684	0.97316	other
E2A-PBX1-C9	other	5e-05	0.99995	other
E2A-PBX1-R1	other	1e-05	0.99999	other
Hyperdip-50-10	other	0.00015	0.99985	other
Hyperdip-50-11 (testset)	other	0.04668	0.95332	other
Hyperdip-50-12	other	1e-04	0.9999	other
Hyperdip-50-13 (testset)	other	3e-05	0.99997	other
Hyperdip-50-14	other	2e-05	0.99998	other
Hyperdip-50-1	other	1e-05	0.99999	other
Hyperdip-50-2	other	1e-05	0.99999	other
Hyperdip-50-3 (testset)	other	0	1	other
Hyperdip-50-4 (testset)	other	0.12366	0.87634	other
Hyperdip-50-5 (testset)	other	0	1	other
Hyperdip-50-6	other	1e-05	0.99999	other
Hyperdip-50-7	other	0	1	other
Hyperdip-50-8 (testset)	other	0	1	other
Hyperdip-50-9	other	1e-05	0.99999	other
Hyperdip-50-2M1	other	3e-05	0.99997	other
Hyperdip-50-2M2 (testset)	other	1e-05	0.99999	other
Hyperdip-50-C10	other	0.00012	0.99988	other
Hyperdip-50-C11 (testset)	other	3e-05	0.99997	other
Hyperdip-50-C12	other	1e-05	0.99999	other
Hyperdip-50-C13	other	2e-05	0.99998	other
Hyperdip-50-C14	other	3e-05	0.99997	other
Hyperdip-50-C15	other	1e-05	0.99999	other
Hyperdip-50-C16	other	0	1	other
Hyperdip-50-C17	other	0.00022	0.99978	other
Hyperdip-50-C18	other	1e-05	0.99999	other
Hyperdip-50-C19 (testset)	other	0	1	other
Hyperdip-50-C1	other	2e-05	0.99998	other
Hyperdip-50-C20	other	3e-05	0.99997	other
Hyperdip-50-C21	other	2e-05	0.99998	other
Hyperdip-50-C22 (testset)	other	0	1	other
Hyperdip-50-C23	other	0	1	other
Hyperdip-50-C24	other	8e-05	0.99992	other
Hyperdip-50-C25	other	1e-05	0.99999	other
Hyperdip-50-C26	other	2e-05	0.99998	other
Hyperdip-50-C27-N	other	2e-05	0.99998	other
Hyperdip-50-C28	other	0	1	other
Hyperdip-50-C29 (testset)	other	2e-05	0.99998	other
Hyperdip-50-C2 (testset)	other	0.00273	0.99727	other
Hyperdip-50-C30	other	1e-05	0.99999	other
Hyperdip-50-C31	other	0	1	other
Hyperdip-50-C32	other	0	1	other
Hyperdip-50-C33	other	0	1	other
Hyperdip-50-C34	other	2e-05	0.99998	other
Hyperdip-50-C35 (testset)	other	0.00011	0.99989	other
Hyperdip-50-C36	other	0	1	other
Hyperdip-50-C37	other	1e-05	0.99999	other
Hyperdip-50-C38	other	1e-05	0.99999	other
Hyperdip-50-C39 (testset)	other	2e-05	0.99998	other
Hyperdip-50-C3	other	0	1	other
Hyperdip-50-C40	other	2e-05	0.99998	other
Hyperdip-50-C41 (testset)	other	3e-05	0.99997	other
Hyperdip-50-C42 (testset)	other	1e-04	0.9999	other
Hyperdip-50-C43	other	3e-05	0.99997	other
Hyperdip-50-C4	other	1e-05	0.99999	other
Hyperdip-50-C5 (testset)	other	0.00555	0.99445	other
Hyperdip-50-C6	other	1e-05	0.99999	other
Hyperdip-50-C7 (testset)	other	0	1	other
Hyperdip-50-C8 (testset)	other	0	1	other
Hyperdip-50-C9	other	0	1	other
Hyperdip-50-R1	other	6e-05	0.99994	other
Hyperdip-50-R2 (testset)	other	1e-05	0.99999	other
Hyperdip-50-R3	other	2e-05	0.99998	other
Hyperdip-50-R4	other	2e-05	0.99998	other
Hyperdip-50-R5 (testset)	other	1e-05	0.99999	other
Hyperdip47-50-1	other	3e-05	0.99997	other
Hyperdip47-50-2	other	4e-05	0.99996	other
Hyperdip47-50-3 (testset)	other	0.83615	0.16385	T-ALL
Hyperdip47-50-2M1 (testset)	other	0	1	other
Hyperdip47-50-C10 (testset)	other	0.00014	0.99986	other
Hyperdip47-50-C11	other	6e-05	0.99994	other
Hyperdip47-50-C12	other	0.00129	0.99871	other
Hyperdip47-50-C13	other	0.00025	0.99975	other
Hyperdip47-50-C14-N (testset)	other	0	1	other
Hyperdip47-50-C15 (testset)	other	0	1	other
Hyperdip47-50-C16	other	0	1	other
Hyperdip47-50-C17	other	6e-05	0.99994	other
Hyperdip47-50-C18	other	0	1	other
Hyperdip47-50-C19	other	0.0021	0.9979	other
Hyperdip47-50-C1 (testset)	other	0	1	other
Hyperdip47-50-C2 (testset)	other	0.00125	0.99875	other
Hyperdip47-50-C3-N (testset)	other	1e-05	0.99999	other
Hyperdip47-50-C4	other	5e-05	0.99995	other
Hyperdip47-50-C5 (testset)	other	0.06545	0.93455	other
Hyperdip47-50-C6 (testset)	other	0.00154	0.99846	other
Hyperdip47-50-C7	other	2e-05	0.99998	other
Hyperdip47-50-C8	other	6e-05	0.99994	other
Hyperdip47-50-C9	other	0	1	other
Hypodip-1 (testset)	other	0.00039	0.99961	other
Hypodip-2	other	0.042	0.958	other
Hypodip-2M1 (testset)	other	0.00427	0.99573	other
Hypodip-C1	other	0.00026	0.99974	other
Hypodip-C2 (testset)	other	2e-05	0.99998	other
Hypodip-C3	other	2e-05	0.99998	other
Hypodip-C4	other	0	1	other
Hypodip-C5	other	7e-05	0.99993	other
Hypodip-C6 (testset)	other	1e-05	0.99999	other
MLL-1 (testset)	other	7e-05	0.99993	other
MLL-2	other	0	1	other
MLL-3 (testset)	other	7e-05	0.99993	other
MLL-4	other	0	1	other
MLL-5 (testset)	other	0	1	other
MLL-6 (testset)	other	0	1	other
MLL-7	other	0	1	other
MLL-8 (testset)	other	1e-05	0.99999	other
MLL-2M1	other	7e-05	0.99993	other
MLL-2M2 (testset)	other	0	1	other
MLL-C1	other	0	1	other
MLL-C2	other	0	1	other
MLL-C3 (testset)	other	0.08975	0.91025	other
MLL-C4	other	1e-05	0.99999	other
MLL-C5	other	0.04796	0.95204	other
MLL-C6	other	0.00111	0.99889	other
MLL-R1 (testset)	other	3e-05	0.99997	other
MLL-R2	other	0	1	other
MLL-R3	other	1e-05	0.99999	other
MLL-R4	other	3e-05	0.99997	other
Normal-1	other	1e-05	0.99999	other
Normal-2	other	0	1	other
Normal-3	other	2e-05	0.99998	other
Normal-C1-N	other	0.00019	0.99981	other
Normal-C10	other	0	1	other
Normal-C11-N (testset)	other	3e-05	0.99997	other
Normal-C12 (testset)	other	3e-05	0.99997	other
Normal-C2-N	other	2e-05	0.99998	other
Normal-C3-N	other	1e-05	0.99999	other
Normal-C4-N	other	2e-05	0.99998	other
Normal-C5	other	0.00022	0.99978	other
Normal-C6 (testset)	other	7e-05	0.99993	other
Normal-C7-N (testset)	other	6e-05	0.99994	other
Normal-C8	other	2e-05	0.99998	other
Normal-C9 (testset)	other	9e-05	0.99991	other
Normal-R1 (testset)	other	7e-05	0.99993	other
Normal-R2-N	other	5e-05	0.99995	other
Normal-R3	other	3e-05	0.99997	other
Pseudodip-1	other	6e-05	0.99994	other
Pseudodip-2	other	0.07239	0.92761	other
Pseudodip-3	other	0.00013	0.99987	other
Pseudodip-4 (testset)	other	6e-05	0.99994	other
Pseudodip-5 (testset)	other	0	1	other
Pseudodip-6 (testset)	other	0	1	other
Pseudodip-7	other	3e-05	0.99997	other
Pseudodip-8-N	other	0	1	other
Pseudodip-9	other	0.00043	0.99957	other
Pseudodip-C10 (testset)	other	0.00096	0.99904	other
Pseudodip-C11 (testset)	other	5e-05	0.99995	other
Pseudodip-C12 (testset)	other	0.00241	0.99759	other
Pseudodip-C13	other	8e-05	0.99992	other
Pseudodip-C14 (testset)	other	7e-05	0.99993	other
Pseudodip-C15	other	2e-05	0.99998	other
Pseudodip-C16-N (testset)	other	0.00128	0.99872	other
Pseudodip-C17	other	7e-05	0.99993	other
Pseudodip-C18	other	0	1	other
Pseudodip-C19	other	0	1	other
Pseudodip-C1	other	7e-05	0.99993	other
Pseudodip-C2-N	other	6e-05	0.99994	other
Pseudodip-C3	other	2e-05	0.99998	other
Pseudodip-C4	other	5e-05	0.99995	other
Pseudodip-C5 (testset)	other	3e-05	0.99997	other
Pseudodip-C6	other	0.00024	0.99976	other
Pseudodip-C7	other	1e-05	0.99999	other
Pseudodip-C8	other	1e-05	0.99999	other
Pseudodip-C9	other	1e-05	0.99999	other
Pseudodip-R1-N (testset)	other	0	1	other
T-ALL-10 (testset)	T-ALL	1	0	T-ALL
T-ALL-1 (testset)	T-ALL	1	0	T-ALL
T-ALL-2 (testset)	T-ALL	0.00691	0.99309	other
T-ALL-3	T-ALL	1	0	T-ALL
T-ALL-4 (testset)	T-ALL	1	0	T-ALL
T-ALL-5 (testset)	T-ALL	1	0	T-ALL
T-ALL-6	T-ALL	1	0	T-ALL
T-ALL-7 (testset)	T-ALL	1	0	T-ALL
T-ALL-8 (testset)	T-ALL	1	0	T-ALL
T-ALL-9	T-ALL	1	0	T-ALL
T-ALL-2M1	T-ALL	1	0	T-ALL
T-ALL-C10	T-ALL	1	0	T-ALL
T-ALL-C11	T-ALL	1	0	T-ALL
T-ALL-C12	T-ALL	1	0	T-ALL
T-ALL-C13	T-ALL	1	0	T-ALL
T-ALL-C14	T-ALL	0.98687	0.01313	T-ALL
T-ALL-C15 (testset)	T-ALL	1	0	T-ALL
T-ALL-C16 (testset)	T-ALL	0.96675	0.03325	T-ALL
T-ALL-C17	T-ALL	0.66358	0.33642	T-ALL
T-ALL-C18	T-ALL	0.97602	0.02398	T-ALL
T-ALL-C19	T-ALL	0.99999	1e-05	T-ALL
T-ALL-C1	T-ALL	0.96201	0.03799	T-ALL
T-ALL-C20	T-ALL	1	0	T-ALL
T-ALL-C21	T-ALL	1	0	T-ALL
T-ALL-C22 (testset)	T-ALL	1	0	T-ALL
T-ALL-C23	T-ALL	0.77737	0.22263	T-ALL
T-ALL-C24 (testset)	T-ALL	1	0	T-ALL
T-ALL-C25 (testset)	T-ALL	1	0	T-ALL
T-ALL-C26	T-ALL	0.99999	1e-05	T-ALL
T-ALL-C2	T-ALL	1	0	T-ALL
T-ALL-C3	T-ALL	1	0	T-ALL
T-ALL-C4	T-ALL	0.99986	0.00014	T-ALL
T-ALL-C5 (testset)	T-ALL	0.00098	0.99902	other
T-ALL-C6	T-ALL	1	0	T-ALL
T-ALL-C7 (testset)	T-ALL	1	0	T-ALL
T-ALL-C8	T-ALL	0.99452	0.00548	T-ALL
T-ALL-C9	T-ALL	1	0	T-ALL
T-ALL-R1	T-ALL	0.99995	5e-05	T-ALL
T-ALL-R2	T-ALL	1	0	T-ALL
T-ALL-R3	T-ALL	1	0	T-ALL
T-ALL-R4	T-ALL	1	0	T-ALL
T-ALL-R5	T-ALL	0.99994	6e-05	T-ALL
T-ALL-R6	T-ALL	0.99816	0.00184	T-ALL
TEL-AML1-10	other	8e-05	0.99992	other
TEL-AML1-11 (testset)	other	1e-05	0.99999	other
TEL-AML1-12	other	0.00203	0.99797	other
TEL-AML1-13 (testset)	other	9e-05	0.99991	other
TEL-AML1-14	other	5e-05	0.99995	other
TEL-AML1-1	other	9e-05	0.99991	other
TEL-AML1-2	other	0.00084	0.99916	other
TEL-AML1-3	other	0.00337	0.99663	other
TEL-AML1-4	other	2e-05	0.99998	other
TEL-AML1-5 (testset)	other	9e-05	0.99991	other
TEL-AML1-6	other	2e-05	0.99998	other
TEL-AML1-7	other	2e-05	0.99998	other
TEL-AML1-8 (testset)	other	7e-05	0.99993	other
TEL-AML1-9	other	0.00041	0.99959	other
TEL-AML1-2M1 (testset)	other	2e-04	0.9998	other
TEL-AML1-2M2	other	8e-05	0.99992	other
TEL-AML1-2M3	other	2e-05	0.99998	other
TEL-AML1-2M4 (testset)	other	0.00097	0.99903	other
TEL-AML1-2M5	other	1e-04	0.9999	other
TEL-AML1-C10	other	0.00029	0.99971	other
TEL-AML1-C11	other	0.00014	0.99986	other
TEL-AML1-C12	other	1e-05	0.99999	other
TEL-AML1-C13	other	1e-05	0.99999	other
TEL-AML1-C14 (testset)	other	6e-05	0.99994	other
TEL-AML1-C15	other	9e-05	0.99991	other
TEL-AML1-C16	other	1e-05	0.99999	other
TEL-AML1-C17	other	9e-05	0.99991	other
TEL-AML1-C18	other	6e-05	0.99994	other
TEL-AML1-C19 (testset)	other	3e-05	0.99997	other
TEL-AML1-C1 (testset)	other	1e-04	0.9999	other
TEL-AML1-C20 (testset)	other	5e-05	0.99995	other
TEL-AML1-C21	other	0.00027	0.99973	other
TEL-AML1-C22	other	0.11058	0.88942	other
TEL-AML1-C23 (testset)	other	1e-05	0.99999	other
TEL-AML1-C24	other	2e-04	0.9998	other
TEL-AML1-C25	other	0.00072	0.99928	other
TEL-AML1-C26 (testset)	other	0.00016	0.99984	other
TEL-AML1-C27	other	4e-05	0.99996	other
TEL-AML1-C28 (testset)	other	0.00018	0.99982	other
TEL-AML1-C29	other	3e-05	0.99997	other
TEL-AML1-C2	other	0.00079	0.99921	other
TEL-AML1-C30	other	0.00034	0.99966	other
TEL-AML1-C31 (testset)	other	3e-05	0.99997	other
TEL-AML1-C32	other	0.00723	0.99277	other
TEL-AML1-C33 (testset)	other	0	1	other
TEL-AML1-C34	other	3e-05	0.99997	other
TEL-AML1-C35	other	0.00016	0.99984	other
TEL-AML1-C36 (testset)	other	9e-05	0.99991	other
TEL-AML1-C37	other	7e-05	0.99993	other
TEL-AML1-C38	other	2e-05	0.99998	other
TEL-AML1-C39	other	2e-05	0.99998	other
TEL-AML1-C3	other	0.00021	0.99979	other
TEL-AML1-C40	other	5e-05	0.99995	other
TEL-AML1-C41	other	0.00075	0.99925	other
TEL-AML1-C42	other	0.00195	0.99805	other
TEL-AML1-C43	other	1e-05	0.99999	other
TEL-AML1-C44	other	9e-05	0.99991	other
TEL-AML1-C45	other	2e-05	0.99998	other
TEL-AML1-C46	other	0.01154	0.98846	other
TEL-AML1-C47	other	1e-05	0.99999	other
TEL-AML1-C48	other	0.32864	0.67136	other
TEL-AML1-C49 (testset)	other	4e-05	0.99996	other
TEL-AML1-C4 (testset)	other	0.00031	0.99969	other
TEL-AML1-C50	other	0.00014	0.99986	other
TEL-AML1-C51 (testset)	other	0.00011	0.99989	other
TEL-AML1-C52	other	0.00175	0.99825	other
TEL-AML1-C53 (testset)	other	0.22534	0.77466	other
TEL-AML1-C54	other	2e-05	0.99998	other
TEL-AML1-C55 (testset)	other	0.00016	0.99984	other
TEL-AML1-C56	other	0.00022	0.99978	other
TEL-AML1-C57	other	5e-04	0.9995	other
TEL-AML1-C5 (testset)	other	0.00036	0.99964	other
TEL-AML1-C6	other	3e-05	0.99997	other
TEL-AML1-C7	other	0.00181	0.99819	other
TEL-AML1-C8	other	0.00047	0.99953	other
TEL-AML1-C9	other	0.00213	0.99787	other
TEL-AML1-R1 (testset)	other	0.00011	0.99989	other
TEL-AML1-R2 (testset)	other	0.00024	0.99976	other
TEL-AML1-R3	other	4e-05	0.99996	other