GO:0006512

GO:0006512

ubiquitin cycle (annotated genes)

Biological Process

Parent node

GO:0006512	ubiquitin cycle

This leaf node contains 61 genes

The following 54 of these are used in classification:

	Symbol	Genename	NORMAL score	other score
39356_at	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.9317	-0.0827
1651_at	UBE2C	ubiquitin-conjugating enzyme E2C	-0.751	0.0666
1357_at	USP4	ubiquitin specific protease 4 (proto-oncogene)	0.6983	-0.0619
369_s_at	UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	-0.5315	0.0471
39083_at	UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.5144	-0.0456
33782_r_at	UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	-0.4594	0.0408
39797_at	C6orf133	chromosome 6 open reading frame 133	0.4322	-0.0383
838_s_at	UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-0.373	0.0331
33781_s_at	UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	-0.3425	0.0304
34374_g_at	UREB1	upstream regulatory element binding protein 1	-0.3293	0.0292
38480_s_at	UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-0.3035	0.0269
39036_g_at	DD5	progestin induced protein	-0.2941	0.0261
36604_at	UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.2921	-0.0259
39035_at	DD5	progestin induced protein	-0.2592	0.023
39039_s_at	UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.2381	-0.0211
33136_at	UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.2258	-0.02
40121_at	HIP2	huntingtin interacting protein 2	-0.2249	0.02
34372_at	UREB1	upstream regulatory element binding protein 1	-0.2248	0.0199
34373_at	UREB1	upstream regulatory element binding protein 1	-0.2223	0.0197
33343_at	RNF14	ring finger protein 14	0.2164	-0.0192
33354_at	SMURF2	E3 ubiquitin ligase SMURF2	0.2103	-0.0187
40623_at	UBE3B	ubiquitin protein ligase	0.2036	-0.0181
37504_at	SMURF1	E3 ubiquitin ligase SMURF1	-0.1861	0.0165
37339_at	USP4	ubiquitin specific protease 4 (proto-oncogene)	0.185	-0.0164
41205_at	UBE3A	ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)	0.1684	-0.0149
1164_at	UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	-0.1549	0.0137
1273_r_at	CDC34	cell division cycle 34	-0.1511	0.0134
1231_at	UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.1504	-0.0133
1660_at	UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	-0.1481	0.0131
38701_at	UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.1403	-0.0124
1274_s_at	CDC34	cell division cycle 34	-0.1295	0.0115
32236_at	UBE2G2	ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)	0.1268	-0.0112
832_at	UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.1263	-0.0112
1193_at	UBE3A	ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)	-0.1248	0.0111
504_at	UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	-0.1208	0.0107
38349_at	ITCH	itchy homolog E3 ubiquitin protein ligase (mouse)	-0.12	0.0106
37358_at	UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	-0.1178	0.0105
40423_at	NACSIN	NPF/calponin-like protein	-0.1163	0.0103
38705_at	UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	-0.1152	0.0102
890_at	UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.1036	-0.0092
40622_r_at	UBE3B	ubiquitin protein ligase	-0.0932	0.0083
785_at	WWP2	Nedd-4-like ubiquitin-protein ligase	0.0879	-0.0078
32078_at	NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.0846	-0.0075
34850_at	UBE2E3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	-0.0664	0.0059
40066_at	UBE1C	ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)	0.0514	-0.0046
33019_at	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.0497	-0.0044
34295_at	USP15	ubiquitin specific protease 15	0.0451	-0.004
39040_at	UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.0429	-0.0038
37750_at	UBE2V2	ubiquitin-conjugating enzyme E2 variant 2	-0.0403	0.0036
37826_at	UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	-0.0383	0.0034
32801_at	KIAA0317	KIAA0317	0.0342	-0.003
35011_at	KIAA0322	HECT type E3 ubiquitin ligase	0.0337	-0.003
35582_at	C6orf133	chromosome 6 open reading frame 133	0.0114	-0.001
223_at	UBE2L3	ubiquitin-conjugating enzyme E2L 3	-0.0012	1e-04

Performance on training data

• Error rate: 0.02222
• Performance: 0.14118
• Redundancy: 3.4113

	Sensitivity	Specificity
NORMAL	0.72727	1
other	1	0.72727

Performance on test data

• Error rate: 0.04412
• Performance: 0.38225
• Redundancy: 3.39112

	Sensitivity	Specificity
NORMAL	0.66667	0.98387
other	0.98387	0.66667

Predictions

	Class	NORMAL	other	Predictionn
CL2001031606AA	other	0.00018	0.99982	other
CL2001031607AA	other	0.00733	0.99267	other
CL2001031608AA	other	0.12208	0.87792	other
CL2001031609AA	other	0.08576	0.91424	other
CL2001031611AA	other	0.00983	0.99017	other
CL2001031612AA	other	0.00368	0.99632	other
CL2001031613AA	other	0.02621	0.97379	other
CL2001031615AA	other	0.0013	0.9987	other
CL2001031616AA (testset)	other	0.0023	0.9977	other
CL2001031618AA	other	0.02774	0.97226	other
CL2001031620AA (testset)	other	0.00589	0.99411	other
CL2001031621AA (testset)	other	0.00027	0.99973	other
CL2001031622AA	other	0.00143	0.99857	other
CL2001031625AA	other	0.01879	0.98121	other
CL2001031627AA (testset)	other	0.00348	0.99652	other
CL2001031628AA (testset)	other	0.00059	0.99941	other
CL2001031629AA	other	1e-04	0.9999	other
CL2001031630AA (testset)	other	0.00988	0.99012	other
CL2001031631AA	other	0.00088	0.99912	other
CL2001031632AA	other	0.00329	0.99671	other
CL2001031634AA	other	0.00098	0.99902	other
CL2001031635AA	other	0.01607	0.98393	other
CL2001031636AA	other	0.00074	0.99926	other
CL2001032002AA	other	0.05002	0.94998	other
CL2001032005AA	other	2e-04	0.9998	other
CL2001032008AA	other	6e-05	0.99994	other
CL2001032009AA (testset)	other	3e-05	0.99997	other
CL2001032010AA (testset)	NORMAL	0.09415	0.90585	other
CL2001032011AA (testset)	other	0.01814	0.98186	other
CL2001032012AA (testset)	other	0.06125	0.93875	other
CL2001032013AA (testset)	other	0.06796	0.93204	other
CL2001032015AA	other	0.11489	0.88511	other
CL2001032016AA (testset)	other	0.04081	0.95919	other
CL2001032019AA	other	0.00343	0.99657	other
CL2001032020AA (testset)	other	0.00048	0.99952	other
CL2001032025AA	other	0.00678	0.99322	other
CL2001032026AA	other	0.08802	0.91198	other
CL2001032027AA	other	0.02606	0.97394	other
CL2001032030AA	other	0.00117	0.99883	other
CL2001032031AA (testset)	other	0.07757	0.92243	other
CL2001032032AA	other	0.14861	0.85139	other
CL2001032034AA	other	0.25708	0.74292	other
CL2001032036AA	other	0.0033	0.9967	other
CL2001032041AA	NORMAL	0.63315	0.36685	NORMAL
CL2001032043AA	NORMAL	0.93561	0.06439	NORMAL
CL2001032044AA	other	0.0055	0.9945	other
CL2001032045AA (testset)	NORMAL	0.74925	0.25075	NORMAL
CL2001032046AA	NORMAL	0.86853	0.13147	NORMAL
CL2001032101AA	other	0.02005	0.97995	other
CL2001032102AA	NORMAL	0.62737	0.37263	NORMAL
CL2001032103AA	other	0.08096	0.91904	other
CL2001032104AA	other	0.02278	0.97722	other
CL2001032105AA	other	0.00042	0.99958	other
CL2001032107AA	other	0.01672	0.98328	other
CL2001032108AA	other	0.0203	0.9797	other
CL2001032109AA (testset)	other	0.44817	0.55183	other
CL2001032110AA	other	0.01936	0.98064	other
CL2001032111AA	other	0.06919	0.93081	other
CL2001032113AA (testset)	other	0.00484	0.99516	other
CL2001032114AA	other	0.01551	0.98449	other
CL2001032115AA (testset)	other	0.08609	0.91391	other
CL2001032116AA (testset)	other	0.1478	0.8522	other
CL2001032117AA	other	0.00514	0.99486	other
CL2001032121AA	other	0.00014	0.99986	other
CL2001032122AA	other	0.00216	0.99784	other
CL2001032124AA	other	0.00928	0.99072	other
CL2001032125AA	other	3e-05	0.99997	other
CL2001032127AA (testset)	other	0.04203	0.95797	other
CL2001032128AA (testset)	NORMAL	0.72403	0.27597	NORMAL
CL2001032129AA (testset)	other	0.00138	0.99862	other
CL2001032130AA	other	1e-04	0.9999	other
CL2001032132AA	other	0.07387	0.92613	other
CL2001032134AA (testset)	other	0.00847	0.99153	other
CL2001032135AA	other	0.03979	0.96021	other
CL2001032136AA (testset)	other	0.01699	0.98301	other
CL2001032138AA (testset)	other	0.00104	0.99896	other
CL2001032141AA (testset)	other	0.00263	0.99737	other
CL2001032142AA	other	0.00125	0.99875	other
CL2001032144AA	other	0.00049	0.99951	other
CL2001032145AA	other	0.04028	0.95972	other
CL2001032147AA	NORMAL	0.40169	0.59831	other
CL2001032149AA (testset)	other	0.02558	0.97442	other
CL2001032151AA	other	0.04668	0.95332	other
CL2001032152AA	other	0.08444	0.91556	other
CL2001032153AA	other	0.00851	0.99149	other
CL2001032155AA	other	0.00504	0.99496	other
CL2001032156AA (testset)	other	0.11638	0.88362	other
CL2001032202AA (testset)	NORMAL	0.62448	0.37552	NORMAL
CL2001032206AA	NORMAL	0.66162	0.33838	NORMAL
CL2001032207AA	other	0.00012	0.99988	other
CL2001032209AA	other	7e-05	0.99993	other
CL2001032210AA	other	0.02553	0.97447	other
CL2001032211AA (testset)	other	0.00068	0.99932	other
CL2001032212AA	other	0.01342	0.98658	other
CL2001032213AA	other	0.06875	0.93125	other
CL2001032214AA (testset)	other	0.15622	0.84378	other
CL2001032217AA (testset)	other	0.00126	0.99874	other
CL2001032218AA	other	0.00072	0.99928	other
CL2001032219AA (testset)	other	0.05968	0.94032	other
CL2001032220AA	NORMAL	0.63383	0.36617	NORMAL
CL2001032222AA (testset)	other	0.00034	0.99966	other
CL2001032229AA (testset)	other	0.02228	0.97772	other
CL2001032231AA	other	0.01323	0.98677	other
CL2001032232AA	other	0.01166	0.98834	other
CL2001032233AA (testset)	other	0.00118	0.99882	other
CL2001032238AA	other	0.03032	0.96968	other
CL2001032239AA	other	0.00518	0.99482	other
CL2001032240AA	other	0.00163	0.99837	other
CL2001032241AA (testset)	other	0.02498	0.97502	other
CL2001032242AA	other	0.00112	0.99888	other
CL2001032243AA	other	0.02671	0.97329	other
CL2001032248AA	other	0.00035	0.99965	other
CL2001032249AA (testset)	other	0.0046	0.9954	other
CL2001032252AA (testset)	other	1e-04	0.9999	other
CL2001032254AA (testset)	other	0.00238	0.99762	other
CL2001032255AA	other	0.01235	0.98765	other
CL2001032256AA (testset)	NORMAL	0.00065	0.99935	other
CL2001032259AA (testset)	other	0.0117	0.9883	other
CL2001032260AA	other	0.00262	0.99738	other
CL2001032301AA	other	0.04484	0.95516	other
CL2001032304AA	NORMAL	0.15009	0.84991	other
CL2001032305AA (testset)	other	0.0016	0.9984	other
CL2001032306AA (testset)	other	0.0081	0.9919	other
CL2001032307AA (testset)	other	0.62166	0.37834	NORMAL
CL2001032308AA	other	0.00224	0.99776	other
CL2001032309AA	other	0.06888	0.93112	other
CL2001032310AA	other	0.01544	0.98456	other
CL2001032311AA (testset)	other	0.00122	0.99878	other
CL2001032312AA	other	0.00388	0.99612	other
CL2001032313AA (testset)	other	0.00473	0.99527	other
CL2001032314AA (testset)	other	0.00141	0.99859	other
CL2001032316AA	other	0.00053	0.99947	other
CL2001032601AA	other	0.00164	0.99836	other
CL2001032602AA	other	0.03015	0.96985	other
CL2001032604AA	other	0.00268	0.99732	other
CL2001032607AA	other	0.01996	0.98004	other
CL2001032608AA	other	0.00827	0.99173	other
CL2001032610AA	other	0.00414	0.99586	other
CL2001032612AA	other	0.00568	0.99432	other
CL2001032613AA (testset)	other	0.00545	0.99455	other
CL2001032614AA	other	0.00476	0.99524	other
CL2001032616AA	other	0.03655	0.96345	other
CL2001032617AA (testset)	other	0.00804	0.99196	other
CL2001032620AA (testset)	other	0.06425	0.93575	other
CL2001032625AA	other	0.00234	0.99766	other
CL2001032627AA	other	0.00059	0.99941	other
CL2001032628AA	other	0.00544	0.99456	other
CL2001032629AA	other	0.01596	0.98404	other
CL2001032630AA (testset)	other	0.00726	0.99274	other
CL2001032632AA	other	0.00376	0.99624	other
CL2001032638AA	other	0.00458	0.99542	other
CL2001032640AA (testset)	other	0.12635	0.87365	other
CL2001032643AA	other	0.00651	0.99349	other
CL2001032644AA (testset)	other	0.00059	0.99941	other
CL2001032647AA	other	0.005	0.995	other
CL2001032701AA	other	0.03772	0.96228	other
CL2001032702AA	other	0.01181	0.98819	other
CL2001032703AA	other	3e-05	0.99997	other
CL2001032704AA	other	0.00509	0.99491	other
CL2001032706AA (testset)	other	0.02632	0.97368	other
CL2001032709AA	other	0.00738	0.99262	other
CL2001032716AA	other	0.00899	0.99101	other
CL2001032717AA	other	0.00388	0.99612	other
CL2001032718AA (testset)	NORMAL	0.96857	0.03143	NORMAL
CL2001032719AA	other	0.01206	0.98794	other
CL2001032720AA	other	0.00982	0.99018	other
CL2001032722AA	other	0.06361	0.93639	other
CL2001032724AA	NORMAL	0.45517	0.54483	other
CL2001032725AA	NORMAL	0.83707	0.16293	NORMAL
CL2001032727AA	NORMAL	0.51923	0.48077	NORMAL
CL2001032729AA	other	0.00086	0.99914	other
CL2001032730AA (testset)	other	0.00817	0.99183	other
CL2001032732AA (testset)	other	0.00535	0.99465	other
CL2001032733AA	other	0.03771	0.96229	other
CL2001032738AA (testset)	other	0.0011	0.9989	other
CL2001032742AA (testset)	other	0.00072	0.99928	other
CL2001032746AA	other	0.00292	0.99708	other
CL2001032747AA	other	0.00578	0.99422	other
CL2001032833AA	other	0.01475	0.98525	other
CL2001032836AA (testset)	other	6e-05	0.99994	other
CL2001032838AA (testset)	other	0.01174	0.98826	other
CL2001032839AA	other	0.00203	0.99797	other
CL2001032841AA	other	0.00584	0.99416	other
CL2001032842AA	other	0.00291	0.99709	other
CL2001032843AA (testset)	other	0.00353	0.99647	other
CL2001032845AA (testset)	other	0.00996	0.99004	other
CL2001032846AA	other	0.00474	0.99526	other
CL2001032847AA	other	0.18844	0.81156	other
CL2001032848AA	other	0.08803	0.91197	other
CL2001032850AA	other	0.02793	0.97207	other
CL2001032853AA	other	0.01259	0.98741	other
CL2001032854AA (testset)	other	0.01014	0.98986	other
CL2001032856AA	other	0.0069	0.9931	other
CL2001032857AA	other	0.1616	0.8384	other
CL2001032860AA (testset)	other	0.00752	0.99248	other
CL2001040305AA	other	0.00102	0.99898	other
CL2001040306AA	other	0.03953	0.96047	other
CL2001041708AA	other	0.00115	0.99885	other
CL2001041711AA	other	0.01394	0.98606	other
CL2001041716AA	other	0.04534	0.95466	other
CL2001042501AA (testset)	other	0.00259	0.99741	other
CL2001042505AA	other	0.00482	0.99518	other
CL2001042506AA (testset)	other	0.01896	0.98104	other