GO:0006511

GO:0006511

ubiquitin-dependent protein catabolism (annotated genes)

Biological Process

Parent node

GO:0006511	ubiquitin-dependent protein catabolism

This leaf node contains 96 genes

The following 76 of these are used in classification:

	Symbol	Genename	NORMAL score	other score
1651_at	UBE2C	ubiquitin-conjugating enzyme E2C	-0.7154	0.0635
1357_at	USP4	ubiquitin specific protease 4 (proto-oncogene)	0.6514	-0.0578
35337_at	FBXO7	F-box only protein 7	0.5252	-0.0466
36990_at	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	-0.5161	0.0458
369_s_at	UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	-0.491	0.0436
39083_at	UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.4751	-0.0421
33247_at	PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	-0.4344	0.0385
38414_at	CDC20	CDC20 cell division cycle 20 homolog (S. cerevisiae)	-0.4169	0.037
33154_at	PSMB4	proteasome (prosome, macropain) subunit, beta type, 4	-0.3968	0.0352
838_s_at	UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-0.3414	0.0303
1311_at	PSMB4	proteasome (prosome, macropain) subunit, beta type, 4	-0.338	0.03
384_at	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	0.3069	-0.0272
951_at	PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.2882	-0.0256
38480_s_at	UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-0.2738	0.0243
39036_g_at	DD5	progestin induced protein	-0.2623	0.0233
37244_at	UCHL3	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	-0.2582	0.0229
38682_at	BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	0.2487	-0.0221
33219_at	USP33	ubiquitin specific protease 33	0.2437	-0.0216
39035_at	DD5	progestin induced protein	-0.2305	0.0204
39582_at	CYLD	cylindromatosis (turban tumor syndrome)	0.2172	-0.0193
38287_at	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)	0.2098	-0.0186
1310_at	PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	-0.209	0.0185
36974_at	PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.2012	-0.0178
33136_at	UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.1951	-0.0173
40121_at	HIP2	huntingtin interacting protein 2	-0.1927	0.0171
1614_s_at	USP6	ubiquitin specific protease 6 (Tre-2 oncogene)	-0.1837	0.0163
33354_at	SMURF2	E3 ubiquitin ligase SMURF2	0.1834	-0.0163
36122_at	PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	-0.1733	0.0154
968_i_at	USP9X	ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)	-0.1594	0.0141
537_f_at	FBXW3	F-box and WD-40 domain protein 3	-0.1545	0.0137
37339_at	USP4	ubiquitin specific protease 4 (proto-oncogene)	0.1539	-0.0137
39794_at	USP8	ubiquitin specific protease 8	0.1415	-0.0126
41205_at	UBE3A	ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)	0.1399	-0.0124
517_at	FBXW3	F-box and WD-40 domain protein 3	-0.1349	0.012
33799_at	SIAH2	seven in absentia homolog 2 (Drosophila)	-0.1345	0.0119
1164_at	UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	-0.126	0.0112
37046_at	PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	-0.1242	0.011
1231_at	UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.1221	-0.0108
37683_at	USP10	ubiquitin specific protease 10	-0.1147	0.0102
32572_at	USP9X	ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)	-0.1138	0.0101
35847_at	USP24	ubiquitin specific protease 24	0.1133	-0.01
38701_at	UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.1117	-0.0099
1309_at	PSMB3	proteasome (prosome, macropain) subunit, beta type, 3	-0.1084	0.0096
41729_at	ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.1073	-0.0095
32236_at	UBE2G2	ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)	0.1014	-0.009
832_at	UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.1006	-0.0089
1193_at	UBE3A	ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)	-0.0973	0.0086
41218_at	USP34	ubiquitin specific protease 34	-0.0958	0.0085
504_at	UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	-0.0954	0.0085
37358_at	UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	-0.0936	0.0083
38705_at	UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	-0.0906	0.008
31847_at	D13S106E	highly charged protein	0.0855	-0.0076
34803_at	USP12	ubiquitin specific protease 12	0.0828	-0.0073
33449_at	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	-0.0824	0.0073
35885_at	USP9Y	ubiquitin specific protease 9, Y-linked (fat facets-like, Drosophila)	0.0795	-0.0071
890_at	UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.0788	-0.007
1447_at	PSMB1	proteasome (prosome, macropain) subunit, beta type, 1	0.0781	-0.0069
34383_at	USP1	ubiquitin specific protease 1	-0.0765	0.0068
38371_at	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	-0.073	0.0065
32170_g_at	FBXO21	F-box only protein 21	0.0722	-0.0064
36492_at	PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	-0.0623	0.0055
39060_at	PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	-0.0588	0.0052
969_s_at	USP9X	ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)	-0.0526	0.0047
32169_at	FBXO21	F-box only protein 21	0.051	-0.0045
36579_at	UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.0495	-0.0044
385_at	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	0.0478	-0.0042
33019_at	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.0256	-0.0023
39465_f_at	SQSTM1	sequestosome 1	-0.0256	0.0023
34295_at	USP15	ubiquitin specific protease 15	0.0216	-0.0019
37826_at	UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	-0.0157	0.0014
38898_at	FBXO21	F-box only protein 21	0.015	-0.0013
386_g_at	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	-0.0142	0.0013
40701_at	USP13	ubiquitin specific protease 13 (isopeptidase T-3)	0.0133	-0.0012
34405_at	USP5	ubiquitin specific protease 5 (isopeptidase T)	-0.0127	0.0011
970_r_at	USP9X	ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)	-0.0121	0.0011
37672_at	USP7	ubiquitin specific protease 7 (herpes virus-associated)	-0.0077	7e-04

Performance on training data

• Error rate: 0.01481
• Performance: 0.16587
• Redundancy: 3.29768

	Sensitivity	Specificity
NORMAL	0.81818	1
other	1	0.81818

Performance on test data

• Error rate: 0.02941
• Performance: 0.39926
• Redundancy: 3.46332

	Sensitivity	Specificity
NORMAL	0.66667	1
other	1	0.66667

Predictions

	Class	NORMAL	other	Predictionn
CL2001031606AA	other	0.00027	0.99973	other
CL2001031607AA	other	0.0048	0.9952	other
CL2001031608AA	other	0.15001	0.84999	other
CL2001031609AA	other	0.20098	0.79902	other
CL2001031611AA	other	0.00306	0.99694	other
CL2001031612AA	other	0.01749	0.98251	other
CL2001031613AA	other	0.01972	0.98028	other
CL2001031615AA	other	0.01407	0.98593	other
CL2001031616AA (testset)	other	0.00199	0.99801	other
CL2001031618AA	other	0.08332	0.91668	other
CL2001031620AA (testset)	other	0.00697	0.99303	other
CL2001031621AA (testset)	other	2e-05	0.99998	other
CL2001031622AA	other	0.00028	0.99972	other
CL2001031625AA	other	0.00251	0.99749	other
CL2001031627AA (testset)	other	0.00213	0.99787	other
CL2001031628AA (testset)	other	0.00112	0.99888	other
CL2001031629AA	other	3e-04	0.9997	other
CL2001031630AA (testset)	other	0.00552	0.99448	other
CL2001031631AA	other	0.00015	0.99985	other
CL2001031632AA	other	0.00183	0.99817	other
CL2001031634AA	other	0.00627	0.99373	other
CL2001031635AA	other	0.02996	0.97004	other
CL2001031636AA	other	0.00017	0.99983	other
CL2001032002AA	other	0.01902	0.98098	other
CL2001032005AA	other	0.00071	0.99929	other
CL2001032008AA	other	7e-05	0.99993	other
CL2001032009AA (testset)	other	0	1	other
CL2001032010AA (testset)	NORMAL	0.0508	0.9492	other
CL2001032011AA (testset)	other	0.02026	0.97974	other
CL2001032012AA (testset)	other	0.00722	0.99278	other
CL2001032013AA (testset)	other	0.06798	0.93202	other
CL2001032015AA	other	0.17093	0.82907	other
CL2001032016AA (testset)	other	0.0027	0.9973	other
CL2001032019AA	other	0.00096	0.99904	other
CL2001032020AA (testset)	other	0.00072	0.99928	other
CL2001032025AA	other	0.00304	0.99696	other
CL2001032026AA	other	0.08315	0.91685	other
CL2001032027AA	other	0.07218	0.92782	other
CL2001032030AA	other	0.00362	0.99638	other
CL2001032031AA (testset)	other	0.0332	0.9668	other
CL2001032032AA	other	0.26697	0.73303	other
CL2001032034AA	other	0.28027	0.71973	other
CL2001032036AA	other	0.00038	0.99962	other
CL2001032041AA	NORMAL	0.71246	0.28754	NORMAL
CL2001032043AA	NORMAL	0.85085	0.14915	NORMAL
CL2001032044AA	other	0.03852	0.96148	other
CL2001032045AA (testset)	NORMAL	0.7277	0.2723	NORMAL
CL2001032046AA	NORMAL	0.86062	0.13938	NORMAL
CL2001032101AA	other	0.13527	0.86473	other
CL2001032102AA	NORMAL	0.55722	0.44278	NORMAL
CL2001032103AA	other	0.15853	0.84147	other
CL2001032104AA	other	0.05424	0.94576	other
CL2001032105AA	other	0.00263	0.99737	other
CL2001032107AA	other	0.00264	0.99736	other
CL2001032108AA	other	0.07016	0.92984	other
CL2001032109AA (testset)	other	0.24246	0.75754	other
CL2001032110AA	other	0.013	0.987	other
CL2001032111AA	other	0.07326	0.92674	other
CL2001032113AA (testset)	other	0.00722	0.99278	other
CL2001032114AA	other	0.01655	0.98345	other
CL2001032115AA (testset)	other	0.15616	0.84384	other
CL2001032116AA (testset)	other	0.00778	0.99222	other
CL2001032117AA	other	0.00031	0.99969	other
CL2001032121AA	other	0.00025	0.99975	other
CL2001032122AA	other	7e-04	0.9993	other
CL2001032124AA	other	0.04894	0.95106	other
CL2001032125AA	other	6e-05	0.99994	other
CL2001032127AA (testset)	other	0.01454	0.98546	other
CL2001032128AA (testset)	NORMAL	0.73203	0.26797	NORMAL
CL2001032129AA (testset)	other	0.00088	0.99912	other
CL2001032130AA	other	0.00024	0.99976	other
CL2001032132AA	other	0.03705	0.96295	other
CL2001032134AA (testset)	other	0.00427	0.99573	other
CL2001032135AA	other	0.01284	0.98716	other
CL2001032136AA (testset)	other	0.02734	0.97266	other
CL2001032138AA (testset)	other	0.00212	0.99788	other
CL2001032141AA (testset)	other	0.00039	0.99961	other
CL2001032142AA	other	0.00229	0.99771	other
CL2001032144AA	other	0.00115	0.99885	other
CL2001032145AA	other	0.15428	0.84572	other
CL2001032147AA	NORMAL	0.28558	0.71442	other
CL2001032149AA (testset)	other	0.02235	0.97765	other
CL2001032151AA	other	0.07148	0.92852	other
CL2001032152AA	other	0.38772	0.61228	other
CL2001032153AA	other	0.00782	0.99218	other
CL2001032155AA	other	0.00899	0.99101	other
CL2001032156AA (testset)	other	0.04654	0.95346	other
CL2001032202AA (testset)	NORMAL	0.68118	0.31882	NORMAL
CL2001032206AA	NORMAL	0.67492	0.32508	NORMAL
CL2001032207AA	other	0.00018	0.99982	other
CL2001032209AA	other	3e-05	0.99997	other
CL2001032210AA	other	0.02532	0.97468	other
CL2001032211AA (testset)	other	6e-05	0.99994	other
CL2001032212AA	other	0.00367	0.99633	other
CL2001032213AA	other	0.28376	0.71624	other
CL2001032214AA (testset)	other	0.10775	0.89225	other
CL2001032217AA (testset)	other	0.00428	0.99572	other
CL2001032218AA	other	0.00299	0.99701	other
CL2001032219AA (testset)	other	0.0639	0.9361	other
CL2001032220AA	NORMAL	0.84606	0.15394	NORMAL
CL2001032222AA (testset)	other	4e-04	0.9996	other
CL2001032229AA (testset)	other	0.01451	0.98549	other
CL2001032231AA	other	0.03664	0.96336	other
CL2001032232AA	other	0.01142	0.98858	other
CL2001032233AA (testset)	other	0.00131	0.99869	other
CL2001032238AA	other	0.20645	0.79355	other
CL2001032239AA	other	0.00047	0.99953	other
CL2001032240AA	other	0.00423	0.99577	other
CL2001032241AA (testset)	other	0.0132	0.9868	other
CL2001032242AA	other	0.00132	0.99868	other
CL2001032243AA	other	0.01018	0.98982	other
CL2001032248AA	other	0.00036	0.99964	other
CL2001032249AA (testset)	other	0.00191	0.99809	other
CL2001032252AA (testset)	other	1e-04	0.9999	other
CL2001032254AA (testset)	other	0.00495	0.99505	other
CL2001032255AA	other	0.0031	0.9969	other
CL2001032256AA (testset)	NORMAL	0.00014	0.99986	other
CL2001032259AA (testset)	other	0.14116	0.85884	other
CL2001032260AA	other	0.00461	0.99539	other
CL2001032301AA	other	0.02642	0.97358	other
CL2001032304AA	NORMAL	0.20211	0.79789	other
CL2001032305AA (testset)	other	0.00047	0.99953	other
CL2001032306AA (testset)	other	0.00247	0.99753	other
CL2001032307AA (testset)	other	0.07354	0.92646	other
CL2001032308AA	other	0.00795	0.99205	other
CL2001032309AA	other	0.09736	0.90264	other
CL2001032310AA	other	0.04073	0.95927	other
CL2001032311AA (testset)	other	0.00012	0.99988	other
CL2001032312AA	other	0.00311	0.99689	other
CL2001032313AA (testset)	other	0.02547	0.97453	other
CL2001032314AA (testset)	other	0.00468	0.99532	other
CL2001032316AA	other	2e-04	0.9998	other
CL2001032601AA	other	0.00273	0.99727	other
CL2001032602AA	other	0.01731	0.98269	other
CL2001032604AA	other	0.00262	0.99738	other
CL2001032607AA	other	0.01303	0.98697	other
CL2001032608AA	other	0.00778	0.99222	other
CL2001032610AA	other	0.00111	0.99889	other
CL2001032612AA	other	0.04197	0.95803	other
CL2001032613AA (testset)	other	0.00151	0.99849	other
CL2001032614AA	other	7e-04	0.9993	other
CL2001032616AA	other	0.08678	0.91322	other
CL2001032617AA (testset)	other	0.00044	0.99956	other
CL2001032620AA (testset)	other	0.05106	0.94894	other
CL2001032625AA	other	0.0123	0.9877	other
CL2001032627AA	other	0.00024	0.99976	other
CL2001032628AA	other	0.0139	0.9861	other
CL2001032629AA	other	0.02273	0.97727	other
CL2001032630AA (testset)	other	0.04367	0.95633	other
CL2001032632AA	other	0.00183	0.99817	other
CL2001032638AA	other	0.00801	0.99199	other
CL2001032640AA (testset)	other	0.00315	0.99685	other
CL2001032643AA	other	0.002	0.998	other
CL2001032644AA (testset)	other	9e-05	0.99991	other
CL2001032647AA	other	0.00323	0.99677	other
CL2001032701AA	other	0.01212	0.98788	other
CL2001032702AA	other	0.00858	0.99142	other
CL2001032703AA	other	1e-04	0.9999	other
CL2001032704AA	other	0.06379	0.93621	other
CL2001032706AA (testset)	other	0.0181	0.9819	other
CL2001032709AA	other	0.01631	0.98369	other
CL2001032716AA	other	0.04203	0.95797	other
CL2001032717AA	other	0.00456	0.99544	other
CL2001032718AA (testset)	NORMAL	0.90806	0.09194	NORMAL
CL2001032719AA	other	0.00412	0.99588	other
CL2001032720AA	other	0.00102	0.99898	other
CL2001032722AA	other	0.07104	0.92896	other
CL2001032724AA	NORMAL	0.55712	0.44288	NORMAL
CL2001032725AA	NORMAL	0.86065	0.13935	NORMAL
CL2001032727AA	NORMAL	0.72434	0.27566	NORMAL
CL2001032729AA	other	0.00177	0.99823	other
CL2001032730AA (testset)	other	0.01346	0.98654	other
CL2001032732AA (testset)	other	0.0013	0.9987	other
CL2001032733AA	other	0.01479	0.98521	other
CL2001032738AA (testset)	other	0.0013	0.9987	other
CL2001032742AA (testset)	other	7e-05	0.99993	other
CL2001032746AA	other	0.00247	0.99753	other
CL2001032747AA	other	0.00253	0.99747	other
CL2001032833AA	other	0.01547	0.98453	other
CL2001032836AA (testset)	other	5e-05	0.99995	other
CL2001032838AA (testset)	other	0.0209	0.9791	other
CL2001032839AA	other	0.0025	0.9975	other
CL2001032841AA	other	0.00565	0.99435	other
CL2001032842AA	other	0.00028	0.99972	other
CL2001032843AA (testset)	other	0.00251	0.99749	other
CL2001032845AA (testset)	other	0.02775	0.97225	other
CL2001032846AA	other	0.00238	0.99762	other
CL2001032847AA	other	0.32951	0.67049	other
CL2001032848AA	other	0.09559	0.90441	other
CL2001032850AA	other	0.15149	0.84851	other
CL2001032853AA	other	0.00908	0.99092	other
CL2001032854AA (testset)	other	0.02683	0.97317	other
CL2001032856AA	other	0.02457	0.97543	other
CL2001032857AA	other	0.1364	0.8636	other
CL2001032860AA (testset)	other	0.02184	0.97816	other
CL2001040305AA	other	0.00497	0.99503	other
CL2001040306AA	other	0.02895	0.97105	other
CL2001041708AA	other	0.01094	0.98906	other
CL2001041711AA	other	0.13169	0.86831	other
CL2001041716AA	other	0.01875	0.98125	other
CL2001042501AA (testset)	other	0.03358	0.96642	other
CL2001042505AA	other	0.02118	0.97882	other
CL2001042506AA (testset)	other	0.10592	0.89408	other