GO:0000398

GO:0000398

nuclear mRNA splicing, via spliceosome (annotated genes)

Biological Process

Parent node

GO:0000398	nuclear mRNA splicing, via spliceosome

This leaf node contains 75 genes

The following 61 of these are used in classification:

	Symbol	Genename	NORMAL score	other score
36846_s_at	LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-0.5053	0.0448
41204_s_at	SF1	splicing factor 1	-0.505	0.0448
35382_at	NOL3	nucleolar protein 3 (apoptosis repressor with CARD domain)	-0.4638	0.0411
32165_at	SFRS7	splicing factor, arginine/serine-rich 7, 35kDa	0.4529	-0.0402
41199_s_at	SFPQ	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	-0.4241	0.0376
36847_r_at	LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-0.4237	0.0376
41224_at	U5-200KD	U5 snRNP-specific protein, 200-KD	-0.3981	0.0353
37507_i_at	FNBP3	formin binding protein 3	-0.3893	0.0345
37463_r_at	SF3A2	splicing factor 3a, subunit 2, 66kDa	-0.3664	0.0325
34717_s_at	FUSIP1	FUS interacting protein (serine-arginine rich) 1	-0.3662	0.0325
36517_at	U2AF1	U2(RNU2) small nuclear RNA auxiliary factor 1	0.3511	-0.0311
40453_s_at	SFRS5	splicing factor, arginine/serine-rich 5	0.3003	-0.0266
33909_at	SF3B4	splicing factor 3b, subunit 4, 49kDa	-0.2974	0.0264
351_f_at	SFRS3	splicing factor, arginine/serine-rich 3	-0.2974	0.0264
37936_at	PRPF4	PRP4 pre-mRNA processing factor 4 homolog (yeast)	-0.2613	0.0232
34716_at	FUSIP1	FUS interacting protein (serine-arginine rich) 1	-0.2503	0.0222
36991_at	SFRS4	splicing factor, arginine/serine-rich 4	0.2497	-0.0222
40711_at	YT521	splicing factor YT521-B	-0.2384	0.0211
37379_at	SF3A3	splicing factor 3a, subunit 3, 60kDa	0.2298	-0.0204
41375_at	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-0.225	0.02
39344_at	TRA2A	transformer-2 alpha	0.2213	-0.0196
36848_r_at	LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-0.2116	0.0188
37935_at	PRPF4	PRP4 pre-mRNA processing factor 4 homolog (yeast)	-0.21	0.0186
41208_at	RNPC7	RNA-binding region (RNP1, RRM) containing 7	0.1973	-0.0175
36226_r_at	SFPQ	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	-0.1954	0.0173
41370_at	HPRP8BP	U5 snRNP-specific 40 kDa protein (hPrp8-binding)	-0.1863	0.0165
37506_at	FNBP3	formin binding protein 3	-0.1855	0.0165
32183_at	SFRS11	splicing factor, arginine/serine-rich 11	-0.1785	0.0158
825_at	PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	-0.1767	0.0157
335_r_at	SF3A2	splicing factor 3a, subunit 2, 66kDa	-0.1717	0.0152
32784_at	PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	-0.1656	0.0147
38352_at	PPIH	peptidyl prolyl isomerase H (cyclophilin H)	-0.1596	0.0142
36005_at	SFRS16	splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)	-0.1517	0.0135
37462_i_at	SF3A2	splicing factor 3a, subunit 2, 66kDa	0.1497	-0.0133
35440_g_at	SF1	splicing factor 1	-0.1436	0.0127
35439_at	SF1	splicing factor 1	0.1421	-0.0126
40122_at	SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	-0.1412	0.0125
40819_at	RBM8A	RNA binding motif protein 8A	0.1411	-0.0125
41203_at	SF1	splicing factor 1	0.1364	-0.0121
35306_at	DHX15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	-0.1348	0.012
36111_s_at	SFRS2	splicing factor, arginine/serine-rich 2	-0.1211	0.0107
40820_at	RBM8A	RNA binding motif protein 8A	-0.1173	0.0104
36224_g_at	SFPQ	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.1159	-0.0103
36223_at	SFPQ	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.0987	-0.0088
32241_at	TARDBP	TAR DNA binding protein	-0.0977	0.0087
37508_f_at	FNBP3	formin binding protein 3	-0.0974	0.0086
39896_at	DHX16	DEAH (Asp-Glu-Ala-His) box polypeptide 16	-0.0917	0.0081
37390_at	DHX38	DEAH (Asp-Glu-Ala-His) box polypeptide 38	0.0873	-0.0077
36225_s_at	SFPQ	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.0798	-0.0071
744_at	DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	-0.076	0.0067
38040_at	SMNDC1	survival motor neuron domain containing 1	-0.0621	0.0055
39725_at	RNPC2	RNA-binding region (RNP1, RRM) containing 2	-0.0609	0.0054
39017_at	LSM1	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-0.0536	0.0048
36033_at	SFRS12	splicing factor, arginine/serine-rich 12	-0.0426	0.0038
39053_at	PRPF3	PRP3 pre-mRNA processing factor 3 homolog (yeast)	-0.0421	0.0037
33744_at	GEMIN4	gem (nuclear organelle) associated protein 4	0.0291	-0.0026
36112_r_at	SFRS2	splicing factor, arginine/serine-rich 2	-0.0181	0.0016
140_s_at	SFRS10	splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)	-0.0084	7e-04
34733_at	SF3A1	splicing factor 3a, subunit 1, 120kDa	0.0039	-3e-04
39897_at	YT521	splicing factor YT521-B	1e-04	0
40638_at	SFPQ	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0	0

Performance on training data

• Error rate: 0.03704
• Performance: 0.23173
• Redundancy: 3.11997

	Sensitivity	Specificity
NORMAL	0.54545	1
other	1	0.54545

Performance on test data

• Error rate: 0.10294
• Performance: 0.48339
• Redundancy: 3.10334

	Sensitivity	Specificity
NORMAL	0.16667	0.96774
other	0.96774	0.16667

Predictions

	Class	NORMAL	other	Predictionn
CL2001031606AA	other	2e-04	0.9998	other
CL2001031607AA	other	0.01076	0.98924	other
CL2001031608AA	other	0.12474	0.87526	other
CL2001031609AA	other	0.33579	0.66421	other
CL2001031611AA	other	0.01227	0.98773	other
CL2001031612AA	other	0.00353	0.99647	other
CL2001031613AA	other	0.00666	0.99334	other
CL2001031615AA	other	0.00904	0.99096	other
CL2001031616AA (testset)	other	0.00746	0.99254	other
CL2001031618AA	other	0.10733	0.89267	other
CL2001031620AA (testset)	other	0.00337	0.99663	other
CL2001031621AA (testset)	other	3e-05	0.99997	other
CL2001031622AA	other	3e-05	0.99997	other
CL2001031625AA	other	0.02019	0.97981	other
CL2001031627AA (testset)	other	0.03872	0.96128	other
CL2001031628AA (testset)	other	0.01446	0.98554	other
CL2001031629AA	other	4e-04	0.9996	other
CL2001031630AA (testset)	other	0.04456	0.95544	other
CL2001031631AA	other	0.00014	0.99986	other
CL2001031632AA	other	0.01858	0.98142	other
CL2001031634AA	other	0.03425	0.96575	other
CL2001031635AA	other	0.00319	0.99681	other
CL2001031636AA	other	0.00037	0.99963	other
CL2001032002AA	other	0.01086	0.98914	other
CL2001032005AA	other	0.00024	0.99976	other
CL2001032008AA	other	1e-04	0.9999	other
CL2001032009AA (testset)	other	0.00022	0.99978	other
CL2001032010AA (testset)	NORMAL	0.02466	0.97534	other
CL2001032011AA (testset)	other	0.01202	0.98798	other
CL2001032012AA (testset)	other	0.0029	0.9971	other
CL2001032013AA (testset)	other	0.19125	0.80875	other
CL2001032015AA	other	0.14934	0.85066	other
CL2001032016AA (testset)	other	0.00145	0.99855	other
CL2001032019AA	other	0.00023	0.99977	other
CL2001032020AA (testset)	other	0.00046	0.99954	other
CL2001032025AA	other	0.03319	0.96681	other
CL2001032026AA	other	0.33617	0.66383	other
CL2001032027AA	other	0.01757	0.98243	other
CL2001032030AA	other	0.00198	0.99802	other
CL2001032031AA (testset)	other	0.20781	0.79219	other
CL2001032032AA	other	0.16465	0.83535	other
CL2001032034AA	other	0.15287	0.84713	other
CL2001032036AA	other	0.01694	0.98306	other
CL2001032041AA	NORMAL	0.78622	0.21378	NORMAL
CL2001032043AA	NORMAL	0.38848	0.61152	other
CL2001032044AA	other	0.1348	0.8652	other
CL2001032045AA (testset)	NORMAL	0.49226	0.50774	other
CL2001032046AA	NORMAL	0.79543	0.20457	NORMAL
CL2001032101AA	other	0.0603	0.9397	other
CL2001032102AA	NORMAL	0.21631	0.78369	other
CL2001032103AA	other	0.45108	0.54892	other
CL2001032104AA	other	0.00681	0.99319	other
CL2001032105AA	other	0.00167	0.99833	other
CL2001032107AA	other	0.00787	0.99213	other
CL2001032108AA	other	0.03019	0.96981	other
CL2001032109AA (testset)	other	0.06602	0.93398	other
CL2001032110AA	other	0.04212	0.95788	other
CL2001032111AA	other	0.0621	0.9379	other
CL2001032113AA (testset)	other	0.04304	0.95696	other
CL2001032114AA	other	0.06203	0.93797	other
CL2001032115AA (testset)	other	0.64006	0.35994	NORMAL
CL2001032116AA (testset)	other	0.01137	0.98863	other
CL2001032117AA	other	0.00584	0.99416	other
CL2001032121AA	other	0.00019	0.99981	other
CL2001032122AA	other	0.00103	0.99897	other
CL2001032124AA	other	0.01843	0.98157	other
CL2001032125AA	other	0.00036	0.99964	other
CL2001032127AA (testset)	other	0.41211	0.58789	other
CL2001032128AA (testset)	NORMAL	0.41315	0.58685	other
CL2001032129AA (testset)	other	0.0023	0.9977	other
CL2001032130AA	other	0.00037	0.99963	other
CL2001032132AA	other	0.00917	0.99083	other
CL2001032134AA (testset)	other	0.00287	0.99713	other
CL2001032135AA	other	0.00101	0.99899	other
CL2001032136AA (testset)	other	0.01641	0.98359	other
CL2001032138AA (testset)	other	0.00275	0.99725	other
CL2001032141AA (testset)	other	0.00783	0.99217	other
CL2001032142AA	other	0.0026	0.9974	other
CL2001032144AA	other	0.00274	0.99726	other
CL2001032145AA	other	0.14147	0.85853	other
CL2001032147AA	NORMAL	0.09016	0.90984	other
CL2001032149AA (testset)	other	0.00501	0.99499	other
CL2001032151AA	other	0.05383	0.94617	other
CL2001032152AA	other	0.42001	0.57999	other
CL2001032153AA	other	0.00187	0.99813	other
CL2001032155AA	other	0.01182	0.98818	other
CL2001032156AA (testset)	other	0.1692	0.8308	other
CL2001032202AA (testset)	NORMAL	0.29736	0.70264	other
CL2001032206AA	NORMAL	0.73595	0.26405	NORMAL
CL2001032207AA	other	0.00316	0.99684	other
CL2001032209AA	other	0.00021	0.99979	other
CL2001032210AA	other	0.05502	0.94498	other
CL2001032211AA (testset)	other	0.00518	0.99482	other
CL2001032212AA	other	0.02704	0.97296	other
CL2001032213AA	other	0.17869	0.82131	other
CL2001032214AA (testset)	other	0.14964	0.85036	other
CL2001032217AA (testset)	other	0.00836	0.99164	other
CL2001032218AA	other	0.00522	0.99478	other
CL2001032219AA (testset)	other	0.56213	0.43787	NORMAL
CL2001032220AA	NORMAL	0.92885	0.07115	NORMAL
CL2001032222AA (testset)	other	4e-05	0.99996	other
CL2001032229AA (testset)	other	0.06721	0.93279	other
CL2001032231AA	other	0.01929	0.98071	other
CL2001032232AA	other	0.01361	0.98639	other
CL2001032233AA (testset)	other	0.00067	0.99933	other
CL2001032238AA	other	0.2804	0.7196	other
CL2001032239AA	other	0.00122	0.99878	other
CL2001032240AA	other	0.00238	0.99762	other
CL2001032241AA (testset)	other	0.01777	0.98223	other
CL2001032242AA	other	0.00175	0.99825	other
CL2001032243AA	other	0.00113	0.99887	other
CL2001032248AA	other	0.00053	0.99947	other
CL2001032249AA (testset)	other	0.03257	0.96743	other
CL2001032252AA (testset)	other	6e-05	0.99994	other
CL2001032254AA (testset)	other	0.00903	0.99097	other
CL2001032255AA	other	0.01199	0.98801	other
CL2001032256AA (testset)	NORMAL	0.00161	0.99839	other
CL2001032259AA (testset)	other	0.0325	0.9675	other
CL2001032260AA	other	0.01017	0.98983	other
CL2001032301AA	other	0.02	0.98	other
CL2001032304AA	NORMAL	0.26329	0.73671	other
CL2001032305AA (testset)	other	0.0065	0.9935	other
CL2001032306AA (testset)	other	0.03362	0.96638	other
CL2001032307AA (testset)	other	0.04633	0.95367	other
CL2001032308AA	other	0.05654	0.94346	other
CL2001032309AA	other	0.01337	0.98663	other
CL2001032310AA	other	0.04533	0.95467	other
CL2001032311AA (testset)	other	0.00109	0.99891	other
CL2001032312AA	other	0.00972	0.99028	other
CL2001032313AA (testset)	other	0.03428	0.96572	other
CL2001032314AA (testset)	other	0.02551	0.97449	other
CL2001032316AA	other	0.00887	0.99113	other
CL2001032601AA	other	0.00612	0.99388	other
CL2001032602AA	other	0.00712	0.99288	other
CL2001032604AA	other	0.02169	0.97831	other
CL2001032607AA	other	0.07189	0.92811	other
CL2001032608AA	other	0.00207	0.99793	other
CL2001032610AA	other	0.01532	0.98468	other
CL2001032612AA	other	0.04502	0.95498	other
CL2001032613AA (testset)	other	0.00851	0.99149	other
CL2001032614AA	other	0.00166	0.99834	other
CL2001032616AA	other	0.1425	0.8575	other
CL2001032617AA (testset)	other	0.01273	0.98727	other
CL2001032620AA (testset)	other	0.22773	0.77227	other
CL2001032625AA	other	0.02523	0.97477	other
CL2001032627AA	other	0.00592	0.99408	other
CL2001032628AA	other	0.0414	0.9586	other
CL2001032629AA	other	0.29311	0.70689	other
CL2001032630AA (testset)	other	0.02484	0.97516	other
CL2001032632AA	other	0.00348	0.99652	other
CL2001032638AA	other	0.01041	0.98959	other
CL2001032640AA (testset)	other	0.07694	0.92306	other
CL2001032643AA	other	0.00885	0.99115	other
CL2001032644AA (testset)	other	0.00014	0.99986	other
CL2001032647AA	other	0.02188	0.97812	other
CL2001032701AA	other	0.07141	0.92859	other
CL2001032702AA	other	0.00098	0.99902	other
CL2001032703AA	other	0.00082	0.99918	other
CL2001032704AA	other	0.01866	0.98134	other
CL2001032706AA (testset)	other	0.00626	0.99374	other
CL2001032709AA	other	0.02571	0.97429	other
CL2001032716AA	other	0.05239	0.94761	other
CL2001032717AA	other	0.02261	0.97739	other
CL2001032718AA (testset)	NORMAL	0.97367	0.02633	NORMAL
CL2001032719AA	other	7e-04	0.9993	other
CL2001032720AA	other	0.00854	0.99146	other
CL2001032722AA	other	0.21569	0.78431	other
CL2001032724AA	NORMAL	0.39817	0.60183	other
CL2001032725AA	NORMAL	0.62557	0.37443	NORMAL
CL2001032727AA	NORMAL	0.86827	0.13173	NORMAL
CL2001032729AA	other	0.00633	0.99367	other
CL2001032730AA (testset)	other	0.0444	0.9556	other
CL2001032732AA (testset)	other	0.00194	0.99806	other
CL2001032733AA	other	0.00869	0.99131	other
CL2001032738AA (testset)	other	0.00382	0.99618	other
CL2001032742AA (testset)	other	0.00558	0.99442	other
CL2001032746AA	other	0.0079	0.9921	other
CL2001032747AA	other	0.05832	0.94168	other
CL2001032833AA	other	0.01081	0.98919	other
CL2001032836AA (testset)	other	1e-05	0.99999	other
CL2001032838AA (testset)	other	0.02243	0.97757	other
CL2001032839AA	other	0.00476	0.99524	other
CL2001032841AA	other	0.01581	0.98419	other
CL2001032842AA	other	0.00208	0.99792	other
CL2001032843AA (testset)	other	0.00077	0.99923	other
CL2001032845AA (testset)	other	0.01204	0.98796	other
CL2001032846AA	other	0.02876	0.97124	other
CL2001032847AA	other	0.23839	0.76161	other
CL2001032848AA	other	0.04733	0.95267	other
CL2001032850AA	other	0.13137	0.86863	other
CL2001032853AA	other	0.0083	0.9917	other
CL2001032854AA (testset)	other	0.02581	0.97419	other
CL2001032856AA	other	0.05715	0.94285	other
CL2001032857AA	other	0.00627	0.99373	other
CL2001032860AA (testset)	other	0.0303	0.9697	other
CL2001040305AA	other	0.0108	0.9892	other
CL2001040306AA	other	0.13136	0.86864	other
CL2001041708AA	other	0.01211	0.98789	other
CL2001041711AA	other	0.05181	0.94819	other
CL2001041716AA	other	0.36376	0.63624	other
CL2001042501AA (testset)	other	0.0706	0.9294	other
CL2001042505AA	other	0.00185	0.99815	other
CL2001042506AA (testset)	other	0.02793	0.97207	other