GO:0007229

GO:0007229

integrin-mediated signaling pathway (annotated genes)

Biological Process

Parent node

GO:0007166	cell surface receptor linked signal transduction

This leaf node contains 53 genes

The following 44 of these are used in classification:

	Symbol	Genename	ADENO score	NORMAL score
32780_at	BPAG1	bullous pemphigoid antigen 1, 230/240kDa	-0.1874	1.4527
41005_at	ITGA8	integrin, alpha 8	-0.1083	0.8392
36709_at	ITGAX	integrin, alpha X (antigen CD11C (p150), alpha polypeptide)	-0.0991	0.7681
39753_at	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	-0.0844	0.6542
35365_at	ILK	integrin-linked kinase	-0.0831	0.6444
36892_at	ITGA7	integrin, alpha 7	-0.0786	0.6094
37574_at	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	-0.0715	0.5539
406_at	ITGB4	integrin, beta 4	0.0685	-0.5308
38547_at	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	-0.0677	0.5244
37918_at	ITGB2	integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)	-0.0594	0.4602
120_at	ITGA1	integrin, alpha 1	-0.0442	0.3425
34974_at	ADAMDEC1	ADAM-like, decysin 1	0.0348	-0.2696
40681_at	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.0338	-0.262
2077_at	ITGA6	integrin, alpha 6	-0.033	0.2561
41266_at	ITGA6	integrin, alpha 6	-0.0309	0.2397
37484_at	ITGA1	integrin, alpha 1	-0.0308	0.2391
39071_at	ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.0288	-0.2232
2055_s_at	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	-0.0259	0.2011
40643_at	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	-0.025	0.1938
37890_at	CD47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.0244	-0.1892
38533_s_at	ITGAM	integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)	-0.0239	0.1851
38746_at	ITGB4	integrin, beta 4	0.0233	-0.1807
35731_at	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	-0.0229	0.1773
39754_at	ITGB5	integrin, beta 5	0.0204	-0.1581
2032_s_at	ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.0203	-0.157
1978_at	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.0171	-0.1329
35948_at	ITGA9	integrin, alpha 9	0.0168	-0.13
852_at	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	-0.0121	0.094
33941_at	ADAM11	a disintegrin and metalloproteinase domain 11	0.0113	-0.0879
884_at	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.0105	-0.0813
37889_at	CD47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.0101	-0.0786
2061_at	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	-0.01	0.0774
1176_at	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	-0.0099	0.0767
312_s_at	PTK2	PTK2 protein tyrosine kinase 2	0.0097	-0.0754
881_at	ITGB6	integrin, beta 6	0.0097	-0.0753
889_at	ITGB8	integrin, beta 8	-0.0097	0.075
40304_at	BPAG1	bullous pemphigoid antigen 1, 230/240kDa	0.0093	-0.0721
36117_at	PTK2	PTK2 protein tyrosine kinase 2	0.0075	-0.0583
1508_at	ITGA9	integrin, alpha 9	-0.0068	0.0527
41481_at	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.0063	-0.0491
40644_g_at	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	-0.0033	0.0259
257_at	ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.0031	-0.0239
37952_at	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.002	-0.0158
33082_at	ITGA10	integrin, alpha 10	-0.0019	0.0145

Performance on training data

• Error rate: 0.01905
• Performance: 0.10331
• Redundancy: 4.63629

	Sensitivity	Specificity
ADENO	0.98925	0.91667
NORMAL	0.91667	0.98925

Performance on test data

• Error rate: 0.01961
• Performance: 0.11536
• Redundancy: 4.97898

	Sensitivity	Specificity
ADENO	0.97826	1
NORMAL	1	0.97826

Predictions

	Class	ADENO	NORMAL	Predictionn
CL2001031608AA	ADENO	0.58216	0.41784	ADENO
CL2001031611AA (testset)	ADENO	0.99763	0.00237	ADENO
CL2001031612AA	ADENO	0.9941	0.0059	ADENO
CL2001031613AA	ADENO	0.77652	0.22348	ADENO
CL2001031615AA	ADENO	0.99881	0.00119	ADENO
CL2001031616AA	ADENO	0.96667	0.03333	ADENO
CL2001031618AA (testset)	ADENO	0.9987	0.0013	ADENO
CL2001031622AA	ADENO	0.9992	8e-04	ADENO
CL2001031625AA (testset)	ADENO	0.99927	0.00073	ADENO
CL2001031627AA	ADENO	0.99847	0.00153	ADENO
CL2001031628AA	ADENO	0.99777	0.00223	ADENO
CL2001031629AA	ADENO	0.99996	4e-05	ADENO
CL2001031630AA	ADENO	0.99998	2e-05	ADENO
CL2001031631AA	ADENO	0.99982	0.00018	ADENO
CL2001031632AA	ADENO	0.99867	0.00133	ADENO
CL2001031634AA	ADENO	0.98238	0.01762	ADENO
CL2001031635AA	ADENO	0.97193	0.02807	ADENO
CL2001031636AA	ADENO	0.83047	0.16953	ADENO
CL2001032002AA	ADENO	0.99993	7e-05	ADENO
CL2001032005AA	ADENO	0.9994	6e-04	ADENO
CL2001032008AA	ADENO	0.9991	9e-04	ADENO
CL2001032009AA (testset)	ADENO	0.99997	3e-05	ADENO
CL2001032011AA	ADENO	0.98889	0.01111	ADENO
CL2001032012AA (testset)	ADENO	0.99321	0.00679	ADENO
CL2001032013AA (testset)	ADENO	0.87097	0.12903	ADENO
CL2001032015AA	ADENO	0.64505	0.35495	ADENO
CL2001032016AA	ADENO	0.9992	8e-04	ADENO
CL2001032019AA	ADENO	0.99623	0.00377	ADENO
CL2001032020AA	ADENO	0.99373	0.00627	ADENO
CL2001032025AA	ADENO	0.99945	0.00055	ADENO
CL2001032026AA	ADENO	0.99949	0.00051	ADENO
CL2001032027AA (testset)	ADENO	0.99854	0.00146	ADENO
CL2001032030AA (testset)	ADENO	0.99984	0.00016	ADENO
CL2001032031AA	ADENO	0.99837	0.00163	ADENO
CL2001032032AA (testset)	ADENO	0.9989	0.0011	ADENO
CL2001032034AA (testset)	ADENO	0.81823	0.18177	ADENO
CL2001032036AA	ADENO	0.99636	0.00364	ADENO
CL2001032103AA	ADENO	0.99056	0.00944	ADENO
CL2001032104AA (testset)	ADENO	0.99996	4e-05	ADENO
CL2001032105AA	ADENO	0.99974	0.00026	ADENO
CL2001032107AA	ADENO	0.99969	0.00031	ADENO
CL2001032108AA (testset)	ADENO	0.99479	0.00521	ADENO
CL2001032109AA	ADENO	0.99805	0.00195	ADENO
CL2001032110AA	ADENO	0.93892	0.06108	ADENO
CL2001032111AA	ADENO	0.9965	0.0035	ADENO
CL2001032113AA	ADENO	0.99992	8e-05	ADENO
CL2001032114AA	ADENO	0.96567	0.03433	ADENO
CL2001032115AA (testset)	ADENO	0.99969	0.00031	ADENO
CL2001032116AA (testset)	ADENO	0.99984	0.00016	ADENO
CL2001032117AA	ADENO	0.99964	0.00036	ADENO
CL2001032125AA (testset)	ADENO	0.99999	1e-05	ADENO
CL2001032130AA	ADENO	0.9985	0.0015	ADENO
CL2001032132AA	ADENO	0.99907	0.00093	ADENO
CL2001032134AA (testset)	ADENO	0.989	0.011	ADENO
CL2001032135AA	ADENO	0.99873	0.00127	ADENO
CL2001032136AA	ADENO	0.99448	0.00552	ADENO
CL2001032138AA	ADENO	0.9704	0.0296	ADENO
CL2001032141AA	ADENO	0.99951	0.00049	ADENO
CL2001032142AA	ADENO	0.99502	0.00498	ADENO
CL2001032149AA (testset)	ADENO	0.99208	0.00792	ADENO
CL2001032155AA (testset)	ADENO	0.90612	0.09388	ADENO
CL2001032156AA	ADENO	0.9874	0.0126	ADENO
CL2001032211AA (testset)	ADENO	0.99906	0.00094	ADENO
CL2001032212AA	ADENO	0.99981	0.00019	ADENO
CL2001032213AA	ADENO	0.44279	0.55721	NORMAL
CL2001032214AA	ADENO	0.65624	0.34376	ADENO
CL2001032229AA	ADENO	0.9992	8e-04	ADENO
CL2001032232AA (testset)	ADENO	0.99985	0.00015	ADENO
CL2001032233AA	ADENO	0.99918	0.00082	ADENO
CL2001032241AA	ADENO	0.98208	0.01792	ADENO
CL2001032242AA	ADENO	0.99897	0.00103	ADENO
CL2001032243AA	ADENO	0.9978	0.0022	ADENO
CL2001032248AA	ADENO	0.99996	4e-05	ADENO
CL2001032249AA (testset)	ADENO	0.99857	0.00143	ADENO
CL2001032252AA	ADENO	0.99716	0.00284	ADENO
CL2001032254AA	ADENO	0.99496	0.00504	ADENO
CL2001032255AA	ADENO	0.9968	0.0032	ADENO
CL2001032259AA	ADENO	0.99225	0.00775	ADENO
CL2001032301AA (testset)	ADENO	0.99717	0.00283	ADENO
CL2001032306AA	ADENO	0.99203	0.00797	ADENO
CL2001032307AA	ADENO	0.94818	0.05182	ADENO
CL2001032308AA (testset)	ADENO	0.99941	0.00059	ADENO
CL2001032309AA	ADENO	0.99933	0.00067	ADENO
CL2001032310AA (testset)	ADENO	0.99985	0.00015	ADENO
CL2001032311AA	ADENO	0.99773	0.00227	ADENO
CL2001032312AA	ADENO	0.99926	0.00074	ADENO
CL2001032313AA (testset)	ADENO	0.99903	0.00097	ADENO
CL2001032314AA (testset)	ADENO	0.99768	0.00232	ADENO
CL2001032316AA	ADENO	0.99674	0.00326	ADENO
CL2001032601AA (testset)	ADENO	0.99932	0.00068	ADENO
CL2001032602AA (testset)	ADENO	0.99996	4e-05	ADENO
CL2001032604AA	ADENO	0.99993	7e-05	ADENO
CL2001032610AA	ADENO	0.99925	0.00075	ADENO
CL2001032612AA	ADENO	0.99909	0.00091	ADENO
CL2001032613AA	ADENO	0.99983	0.00017	ADENO
CL2001032614AA	ADENO	0.99996	4e-05	ADENO
CL2001032616AA (testset)	ADENO	0.99938	0.00062	ADENO
CL2001032617AA (testset)	ADENO	0.99977	0.00023	ADENO
CL2001032620AA	ADENO	0.99833	0.00167	ADENO
CL2001032625AA	ADENO	0.99996	4e-05	ADENO
CL2001032628AA	ADENO	0.99562	0.00438	ADENO
CL2001032638AA (testset)	ADENO	0.99938	0.00062	ADENO
CL2001032640AA	ADENO	0.99998	2e-05	ADENO
CL2001032643AA (testset)	ADENO	0.97576	0.02424	ADENO
CL2001032647AA	ADENO	0.98626	0.01374	ADENO
CL2001032701AA (testset)	ADENO	0.99953	0.00047	ADENO
CL2001032702AA	ADENO	0.99948	0.00052	ADENO
CL2001032703AA (testset)	ADENO	0.98614	0.01386	ADENO
CL2001032704AA (testset)	ADENO	0.98449	0.01551	ADENO
CL2001032706AA	ADENO	0.9994	6e-04	ADENO
CL2001032709AA	ADENO	0.9991	9e-04	ADENO
CL2001032716AA	ADENO	0.99969	0.00031	ADENO
CL2001032717AA	ADENO	0.99943	0.00057	ADENO
CL2001032729AA	ADENO	0.99961	0.00039	ADENO
CL2001032730AA	ADENO	0.99892	0.00108	ADENO
CL2001032733AA (testset)	ADENO	0.99994	6e-05	ADENO
CL2001032738AA (testset)	ADENO	0.9935	0.0065	ADENO
CL2001032742AA	ADENO	0.99981	0.00019	ADENO
CL2001032746AA	ADENO	0.9932	0.0068	ADENO
CL2001032747AA	ADENO	0.99979	0.00021	ADENO
CL2001032833AA (testset)	ADENO	0.99981	0.00019	ADENO
CL2001032836AA	ADENO	0.99993	7e-05	ADENO
CL2001032838AA	ADENO	0.99449	0.00551	ADENO
CL2001032839AA	ADENO	0.99893	0.00107	ADENO
CL2001032841AA (testset)	ADENO	0.99875	0.00125	ADENO
CL2001032842AA	ADENO	0.99997	3e-05	ADENO
CL2001032843AA (testset)	ADENO	0.99997	3e-05	ADENO
CL2001032845AA (testset)	ADENO	0.99338	0.00662	ADENO
CL2001032846AA	ADENO	0.99977	0.00023	ADENO
CL2001032848AA (testset)	ADENO	0.11814	0.88186	NORMAL
CL2001032856AA	ADENO	0.98407	0.01593	ADENO
CL2001032857AA	ADENO	0.99978	0.00022	ADENO
CL2001040305AA (testset)	ADENO	0.99974	0.00026	ADENO
CL2001040306AA (testset)	ADENO	0.99902	0.00098	ADENO
CL2001041708AA (testset)	ADENO	0.99984	0.00016	ADENO
CL2001041711AA	ADENO	0.99991	9e-05	ADENO
CL2001041716AA	ADENO	0.98738	0.01262	ADENO
CL2001042505AA (testset)	ADENO	0.9999	1e-04	ADENO
CL2001042506AA	ADENO	0.88657	0.11343	ADENO
CL2001032010AA (testset)	NORMAL	0.06168	0.93832	NORMAL
CL2001032041AA	NORMAL	0.00928	0.99072	NORMAL
CL2001032043AA (testset)	NORMAL	0.02174	0.97826	NORMAL
CL2001032045AA	NORMAL	0.18876	0.81124	NORMAL
CL2001032046AA	NORMAL	0.10222	0.89778	NORMAL
CL2001032102AA	NORMAL	0.01989	0.98011	NORMAL
CL2001032128AA (testset)	NORMAL	0.0314	0.9686	NORMAL
CL2001032147AA	NORMAL	0.00126	0.99874	NORMAL
CL2001032202AA	NORMAL	0.00579	0.99421	NORMAL
CL2001032206AA (testset)	NORMAL	0.03894	0.96106	NORMAL
CL2001032220AA	NORMAL	0.1411	0.8589	NORMAL
CL2001032256AA	NORMAL	0.46085	0.53915	NORMAL
CL2001032304AA	NORMAL	0.12896	0.87104	NORMAL
CL2001032718AA	NORMAL	0.03202	0.96798	NORMAL
CL2001032724AA	NORMAL	0.5557	0.4443	ADENO
CL2001032725AA (testset)	NORMAL	0.09203	0.90797	NORMAL
CL2001032727AA	NORMAL	0.06732	0.93268	NORMAL